Gene Details:

Gene ID Chr. No. Start Position End Position Function View on
Vu_02086 LG1 25666911 25679462 PREDICTED: mitogen-activated protein kinase kinase kinase 1
Map

Annotations  
category   relationship type   keyword
Biological Process   involved in   root meristem growth, cold acclimation, protein autophosphorylation, root system development, response to salt stress, response to cold, response to cold, response to cadmium ion, response to wounding, protein autophosphorylation, root meristem growth, response to osmotic stress, response to cold, root system development, protein autophosphorylation, response to cold, response to L-glutamate, response to osmotic stress, response to osmotic stress, response to osmotic stress, root meristem growth, MAPK cascade, cold acclimation, response to salt stress
Cellular Component   located in   endosome, nucleus, nucleus, plasma membrane
Molecular Function   enables   MAP kinase kinase kinase activity, protein binding, protein binding, protein serine/threonine kinase activity, MAP kinase kinase kinase activity, MAP kinase kinase kinase activity, protein serine/threonine kinase activity, protein binding, protein serine/threonine kinase activity, protein binding, protein serine/threonine kinase activity, MAP kinase kinase kinase activity, kinase binding, MAP kinase kinase kinase activity, MAP kinase kinase kinase activity, protein binding, protein serine/threonine kinase activity, MAP kinase kinase kinase activity, MAP kinase kinase kinase activity, DNA binding, protein binding, MAP kinase kinase kinase activity, protein serine/threonine kinase activity, protein binding
Pathway   B 09132 Signal transduction   C 04016 MAPK signaling pathway - plant [PATH:ko04016]
SNP Position Effect Amino acid change
G/T 25666959 5_prime_UTR_premature_start_codon_gain_variant
G/A 25667109 synonymous_variant p.Thr24Thr
G/C 25667124 missense_variant p.Gln29His
T/A 25667227 missense_variant p.Ser64Thr
T/A 25667246 missense_variant p.Phe70Tyr
T/C 25667322 synonymous_variant p.Cys95Cys
T/C 25667343 synonymous_variant p.Gly102Gly
C/T 25667367 synonymous_variant p.Thr110Thr
G/T 25667677 stop_gained p.Glu214*
G/A 25667781 synonymous_variant p.Val248Val
G/T 25667802 missense_variant p.Glu255Asp
A/C 25667805 missense_variant p.Glu256Asp
C/T 25667810 missense_variant p.Ala258Val
G/A 25667812 missense_variant p.Ala259Thr
C/A 25667813 missense_variant p.Ala259Glu
G/A 25667823 synonymous_variant p.Ala262Ala
G/A 25667824 missense_variant p.Asp263Asn
T/C 25667829 synonymous_variant p.Ile264Ile
C/T 25667862 synonymous_variant p.Asn275Asn
G/T 25667869 missense_variant p.Asp278Tyr
A/G 25667887 missense_variant p.Thr284Ala
G/A 25667889 synonymous_variant p.Thr284Thr
C/T 25667900 missense_variant p.Ser288Phe
C/T 25667915 missense_variant p.Pro293Leu
G/A 25667933 missense_variant p.Arg299His
C/T 25667943 synonymous_variant p.Thr302Thr
G/A 25667944 missense_variant p.Ala303Thr
A/G 25667946 synonymous_variant p.Ala303Ala
G/A 25667955 stop_gained p.Trp306*
G/A 25667974 missense_variant p.Gly313Arg
C/T 25667984 missense_variant p.Ser316Leu
C/T 25668026 intron_variant
T/A 25668091 intron_variant
G/A 25668120 intron_variant
A/G 25668123 intron_variant
G/C 25668204 intron_variant
C/T 25668208 intron_variant
G/A 25668219 intron_variant
G/A 25668232 intron_variant
C/T 25668250 intron_variant
C/A,G 25668263 intron_variant
T/C 25668269 intron_variant
T/C 25668285 intron_variant
G/A 25668290 intron_variant
G/A 25668318 intron_variant
G/A 25668321 intron_variant
A/G 25668367 intron_variant
A/T 25668370 intron_variant
A/G 25668386 intron_variant
G/A 25668410 intron_variant
G/A 25668420 intron_variant
C/A,* 25668429 intron_variant
G/C 25668542 intron_variant
C/T 25668566 intron_variant
T/C 25668769 intron_variant
T/A 25668770 intron_variant
T/G 25668771 intron_variant
G/A 25668875 intron_variant
A/T 25668901 intron_variant
A/T 25668905 intron_variant
A/G 25668913 intron_variant
C/A 25668919 intron_variant
A/T 25668921 intron_variant
T/C 25669022 intron_variant
G/A 25669043 intron_variant
A/T 25669073 intron_variant
A/G 25669074 intron_variant
G/T 25669075 intron_variant
G/T,A 25669099 intron_variant
T/A 25669107 intron_variant
T/G 25669209 intron_variant
A/G 25669377 intron_variant
C/G 25669468 intron_variant
T/G 25669513 intron_variant
G/T 25669545 intron_variant
A/G 25669642 missense_variant&splice_region_variant p.Gln354Arg
T/A 25669650 splice_region_variant&intron_variant
C/A 25669669 intron_variant
G/A 25669684 intron_variant
T/C 25669718 intron_variant
C/A 25669720 intron_variant
T/C 25669724 intron_variant
T/C 25669842 intron_variant
A/T 25669869 intron_variant
A/T 25669917 intron_variant
A/G 25670326 intron_variant
G/A 25670664 intron_variant
T/C 25670841 intron_variant
T/C 25670885 synonymous_variant p.Phe383Phe
C/T 25671180 intron_variant
G/A 25671295 intron_variant
G/T 25671382 intron_variant
T/C 25671454 intron_variant
G/A 25671458 intron_variant
G/A 25671555 intron_variant
T/C 25671689 intron_variant
A/T 25671737 intron_variant
A/T 25671738 intron_variant
C/T 25671740 intron_variant
G/C,T 25671803 missense_variant p.Val437Leu
T/G 25671820 synonymous_variant p.Ser442Ser
G/A 25671844 synonymous_variant p.Leu450Leu
G/A 25671853 splice_region_variant&intron_variant
G/A 25671963 splice_acceptor_variant&intron_variant
G/A 25672003 missense_variant p.Ala466Thr
G/A 25672010 stop_gained p.Trp468*
G/T,* 25672028 splice_region_variant&intron_variant
C/A 25672029 splice_region_variant&intron_variant
T/C 25672050 intron_variant
A/G 25672064 intron_variant
T/A 25672066 intron_variant
G/A 25672068 intron_variant
T/C 25672086 intron_variant
G/T 25672124 intron_variant
G/A 25672146 intron_variant
A/G 25672306 intron_variant
C/T 25672362 intron_variant
T/C 25672430 intron_variant
T/A 25672651 intron_variant
T/A 25672812 intron_variant
A/G 25672813 intron_variant
A/G 25673033 intron_variant
G/T 25673034 intron_variant
G/A 25673058 intron_variant
T/G 25673146 intron_variant
C/T 25673347 intron_variant
A/G 25673522 intron_variant
T/C 25673570 intron_variant
A/C 25673819 intron_variant
G/C 25673828 intron_variant
A/T 25673833 intron_variant
T/A 25673879 intron_variant
C/G 25673913 intron_variant
C/A 25673915 intron_variant
T/C 25673931 intron_variant
G/A 25674130 intron_variant
A/T 25674167 intron_variant
G/A 25674639 intron_variant
G/T 25674642 intron_variant
C/A 25674700 intron_variant
C/A 25674823 synonymous_variant p.Pro525Pro
C/T 25674994 3_prime_UTR_variant
A/T 25675308 intron_variant
G/A 25675417 intron_variant
A/C 25675558 intron_variant
T/A 25675609 intron_variant
G/C 25675790 intron_variant
A/T 25675964 intron_variant
C/T 25675972 intron_variant
G/A 25675980 intron_variant
G/A 25676017 intron_variant
C/A 25676022 intron_variant
C/T 25676073 intron_variant
A/G 25676121 intron_variant
G/T 25676319 intron_variant
T/C 25676357 intron_variant
C/T 25676379 intron_variant
C/A 25676401 intron_variant
A/G 25676900 intron_variant
A/C 25677175 intron_variant
C/A 25677298 intron_variant
G/C 25677309 intron_variant
A/T 25677344 intron_variant
C/T 25677437 intron_variant
T/G 25677462 intron_variant
C/T 25677552 intron_variant
T/G 25677774 intron_variant
C/T 25677907 intron_variant
G/A 25678103 intron_variant
C/T 25678149 intron_variant
C/T 25678442 intron_variant
G/T 25678719 intron_variant
A/T 25678720 intron_variant
T/C 25678871 intron_variant
A/T 25678880 intron_variant
C/A 25678909 intron_variant
A/C 25678963 intron_variant
A/G 25679135 3_prime_UTR_variant
C/T 25679277 3_prime_UTR_variant
A/G 25679341 3_prime_UTR_variant
T/A 25679419 3_prime_UTR_variant

View accession wise SNPs


Sequence Details:

Protein Sequence:
>Vu_02086.1
MNHLPRLFGNRKKPPNMDPKKSKTRGKKQQPKLERRNAAKHFEYDAGSSSSLRGDSASVSTSSSSSSSLFTRSMDFYGHRSFRIDGVEGEFDRICQSLGLSGPEDFSIPTAAWEAMKLRSSSDIPLLRNHDGKALDEEAKEKEEIEAVESEYEARVLDECVVPAESSGCCTAGGGGIKGFRPPMLKPPPGIRVSVVDETCSTWDLLRDFAPKGEGGKETYVELSASDEDEDGEVKEEEDEEEGEVGGVRVEREEEENAARIADIVDEFSGFSTSNEDDSSSTTTGPNSSNISPNGRIKRVITAGNWQKGELLGRGSFGYVYEGISEDGFFFAVKQVSLLDQGNQGRQSVYQLEQEIALLSQFEHENIVQYFGTEMDASNLYIFIELVTKGSLRNLYQTYTLRDSQVSAYTRQILHGLKYLHDRNIVHRDIKCANILVDANGSVKLSDFGLAKAIKLNDVKSCKGTAFWMAPEVVKGKQKGYGLPADIWSLGCTVLEMLTGQFPYSHLECMQALFRIGRGEPPIVPDSLSRDAQDFILQCLKVNPDERPSAAKLLNHTFVQRPLLSQTSGSASPYIRRG*


CDS Sequence:
>Vu_02086.1
ATGAATCACCTACCTCGACTATTCGGCAATAGAAAGAAGCCTCCAAACATGGACCCCAAGAAGAGCAAGACGCGAGGCAAGAAGCAGCAGCCCAAGCTCGAGCGCCGCAACGCCGCCAAGCACTTCGAATACGACGCCGGATCGTCGTCTTCTTTGCGAGGTGACTCCGCATCCGTCTCCACGTCGTCTTCCTCGTCGTCTTCGTTATTTACGCGTTCAATGGACTTCTACGGCCACCGGAGCTTCCGAATCGATGGCGTGGAGGGCGAGTTCGACCGGATTTGTCAAAGCCTCGGCCTCTCCGGTCCGGAGGACTTCTCCATTCCGACCGCCGCCTGGGAGGCCATGAAGCTCCGCTCCTCCTCCGACATCCCGTTGCTCCGGAACCACGACGGGAAGGCGTTGGACGAGGAGGCGAAGGAGAAGGAGGAAATTGAAGCGGTTGAGAGCGAGTATGAGGCTAGGGTTTTGGATGAGTGTGTTGTTCCTGCTGAGAGCAGTGGTTGCTGCACCGCTGGCGGCGGAGGAATTAAGGGTTTTCGGCCTCCGATGCTGAAGCCGCCGCCAGGGATTAGGGTTTCGGTGGTGGACGAGACGTGTTCGACATGGGATTTGTTGCGGGATTTTGCGCCGAAAGGGGAGGGAGGGAAGGAGACTTACGTGGAGTTGAGTGCTTCTGATGAAGATGAGGACGGAGAAGTAAAGGAAGAGGAGGATGAGGAAGAAGGGGAAGTTGGTGGAGTGAGGGTGGAGAGAGAAGAGGAGGAAAACGCGGCGAGGATTGCGGATATTGTGGATGAGTTTTCTGGGTTTTCTACTTCGAACGAAGATGATTCTTCTAGCACTACCACGGGTCCTAATTCTAGTAATATATCTCCTAATGGGAGAATCAAGCGTGTGATTACCGCAGGTAACTGGCAGAAGGGTGAGCTTTTGGGGCGTGGTTCGTTTGGCTATGTCTATGAAGGGATTTCTGAAGATGGATTCTTTTTTGCTGTAAAACAAGTTTCACTACTTGATCAGGGGAATCAGGGAAGGCAAAGTGTATATCAACTGGAACAGGAAATTGCACTTTTGAGTCAATTTGAACACGAGAATATAGTTCAATACTTTGGCACTGAAATGGATGCGTCAAATCTGTATATCTTTATTGAGCTTGTAACTAAAGGATCCCTTAGAAATCTCTACCAGACATATACTCTTCGAGATTCTCAAGTATCTGCTTATACAAGGCAGATTTTGCATGGTTTAAAGTATCTCCATGATCGAAACATCGTTCACAGGGATATTAAATGTGCAAATATATTGGTGGATGCGAATGGATCTGTTAAGCTTTCAGATTTTGGATTGGCGAAGGCAATCAAATTGAATGATGTTAAATCATGCAAGGGAACAGCATTCTGGATGGCCCCAGAGGTTGTGAAAGGTAAACAAAAAGGTTACGGGCTTCCAGCTGATATATGGAGTCTTGGATGTACTGTGTTAGAGATGTTAACTGGCCAATTTCCATACTCTCACTTAGAATGTATGCAGGCATTGTTTAGAATTGGAAGAGGCGAGCCCCCTATTGTGCCCGATTCCCTTTCAAGAGATGCACAAGATTTTATCCTGCAGTGTCTCAAAGTTAATCCAGATGAACGTCCCAGTGCTGCTAAACTCCTAAACCATACCTTTGTCCAAAGGCCGCTACTTTCCCAGACCTCTGGTTCTGCATCTCCTTATATTCGAAGGGGTTAA


Promoter Sequence:
>Vu_02086::LG1:25664911-25666911(+)
AAGGGTTAAATATGTTTTTAGTCCCTAAACTATTGGCCTTTTCTGGTTTTCGTCCCTCTTTCAAAGTAAGGTACAATTTGATCCTCATTCTTTTCGAAACGTTCGTTTTAGTCCTCGGAATTTTGGTTTTAGTCCTCATTTTGTTGCTAAATGAGGACCAAATTTTTAAACGGTGTTAGTTTTCGAGGACTAAAACGAACGTTTTCGAAAAGAATGAGGGCCAAATTATACCTTACTTTGAAAGAGGGACGAAAACCAGAAACGACCAATAGTTTAGGGACTAAAAACATATTTAACCCAAATTATAAAATGAAACTCATTATAAAATCATTTTTTGTAAGAAATTGTTTAACAACGAGTGTTTCTGATTTTTTCCAAGCCAATTACCAATTCCTTTGATGTCATTATGCTTGTGAAAATTAGATAAAATTACATAAGACAAAAATTATAAAATGAAAACTCATTATAAAATCATTTTTTGTAAGAAGTTGTTTAACAACGAGTATTTCTGATTTTTTTCGAGGTCAATTACCAATTCCTTTATATTTGTGAAATTGGATAAAATTAGATAAGACAAAAATTATAAAATGAAAACTCATTATAAAATCATTTTTTGTAAGATTGTTTAAGGGCAAATGTTTCTGATTTTTTGAATTGGGGCTATAGTAGGGATGACAGAGAAAATGTTGGAATGAGAGAGATGAAAAAGAAAGGGTTGAGAGGAATTAACCTTAAAACTTAGAATCCATGGTATATAAGGGTATTTTTGTCCACTAAAACCCGGTACACATTGCTAAAATGTAGAAAAACAGGCAAAGGTTGACATATTCACCTTCAGGCAAAGGTTCATTCAAGATCTCTTCAATTTCACCATCTTTAGTAACCTCTATAATTTCATCATCTACAGAGGTTGAATCATCATCTCTAAAAAATTATATACGACAAAAATTATAAGGGTTAAATATGTTTTTAGTCCCTAAACTATTGCCCGTTTCTGGTTTTCGTCCCTCTTTCAAAGTAAGGTACAATTTGGTTCTCATTCTTTTCGAAACGTTCGTTTTAGTCCTCGAAATTTTGGTTGTAGTCCTCATTTTGTTGCTAAATGAGGACTAAATTTTTAAACGGTGTTAGTTTTCGAGGACTAAAACGAACGTTTTCGAAAAGAATGAGGACCAAATTGTACCTTACTTTGAAAGAGGGACGAAAATCAGAAACGACCAACAGTTTAGGGACTAAAAACATATTTAACCCAAAATTATAAAATGAAAACTCATTATAAAATCATTTTTTGTAAGAAATTGTTTAACAAAGAGAAAGAGTTGAGAGGAATGATAGAGTGTGAGTAAGGGTTTGAGGTTTTTTTTTTAGTTTTGAGAATGAAAATTATTAAAATACTCTTAACCTTAAAACTTAGAATCCATGGTATATAAGGGTATTTTTGTCCACTAAAACCCGGTACACATTGCTAAAATGTAGAAAAACAGGCGTACGCGCGTTAGCAAACCCCTATATATATATATAATATAATTATTTAAAAATAAATTTAACAAAATAAATTTAAGAATACTGTAATAAATAATTAAATTAAATATTTAATTTTTTTCACTGCGTATCAATCACATAATCTATTATCCTTCCACTCATTTTACTTATTTTCTTATATTCATTAATTTCACTCTTTTAATTCTCTTTTTCTTCCCTTTCCAGTCCTGCCTGTAAATAGCTATTGTACATGTCAATGCTCTTACAGAAGACTAATAATAATTATGTATTTAAAGAAAATAGAAGTAAAGATTTTTTATTTATTTCATTTTACATCCAGCAATTAATGATGATGGATGAATTTACAAAGTGAGGCCGGACGAAGCGAGGTACAATGTTAGCACAGAAGAAAGTGGAAAAGCTAGTCGAGTTGGAGAATCCGAGTCACGTGTAGGTGATCCACGTGGCACCGCGTTTTCTGTCCCTTTTTACTTGGGCGTTTACCAGCTCTTATCGTA


Gene Sequence:
>Vu_02086(+)
ACGCTACCTTTCTTTCTGCCCCTTTCACATAACTACTCATTTTATTTTGTGCACCTCTGGAAAAGGTGAACACTCTAAGCGTTGCGTTTCCCCGGTCCGACGAGGGTTTAGATGGATTTGGCGAGCCATGAATCACCTACCTCGACTATTCGGCAATAGAAAGAAGCCTCCAAACATGGACCCCAAGAAGAGCAAGACGCGAGGCAAGAAGCAGCAGCCCAAGCTCGAGCGCCGCAACGCCGCCAAGCACTTCGAATACGACGCCGGATCGTCGTCTTCTTTGCGAGGTGACTCCGCATCCGTCTCCACGTCGTCTTCCTCGTCGTCTTCGTTATTTACGCGTTCAATGGACTTCTACGGCCACCGGAGCTTCCGAATCGATGGCGTGGAGGGCGAGTTCGACCGGATTTGTCAAAGCCTCGGCCTCTCCGGTCCGGAGGACTTCTCCATTCCGACCGCCGCCTGGGAGGCCATGAAGCTCCGCTCCTCCTCCGACATCCCGTTGCTCCGGAACCACGACGGGAAGGCGTTGGACGAGGAGGCGAAGGAGAAGGAGGAAATTGAAGCGGTTGAGAGCGAGTATGAGGCTAGGGTTTTGGATGAGTGTGTTGTTCCTGCTGAGAGCAGTGGTTGCTGCACCGCTGGCGGCGGAGGAATTAAGGGTTTTCGGCCTCCGATGCTGAAGCCGCCGCCAGGGATTAGGGTTTCGGTGGTGGACGAGACGTGTTCGACATGGGATTTGTTGCGGGATTTTGCGCCGAAAGGGGAGGGAGGGAAGGAGACTTACGTGGAGTTGAGTGCTTCTGATGAAGATGAGGACGGAGAAGTAAAGGAAGAGGAGGATGAGGAAGAAGGGGAAGTTGGTGGAGTGAGGGTGGAGAGAGAAGAGGAGGAAAACGCGGCGAGGATTGCGGATATTGTGGATGAGTTTTCTGGGTTTTCTACTTCGAACGAAGATGATTCTTCTAGCACTACCACGGGTCCTAATTCTAGTAATATATCTCCTAATGGGAGAATCAAGCGTGTGATTACCGCAGGTAACTGGCAGAAGGGTGAGCTTTTGGGGCGTGGTTCGTTTGGCTATGTCTATGAAGGGATTTCTGAGTAAGTGCTTTCGAGCCCATCACTTCGCTTATACTCGCTCAAAGTTATTGTTAGAAACGAAAGATAAGCCTTATTGTTTATTTCATTGTTTACTGTGGTGTTGGAGTTAGAGAATAGGGATCCAGATGGTGTGGTGGTAGTAAGTAACATTACAATGTTGTGTTAAGAGAAAGAGAAACAATTATAGTAGGGCCAGTGAGAACAGTTTCAGGGATTCGGTTCATCTATTTTATTCCTCTCTTTCTACTCAAATCTTTGTAGGATACTATGTTATGGAATGTTAGTGTTAGAATTAGGAGATTGGCAGGTTAGTTGTAGAAGGTTTGGATATGAGAATATGTTGGAAAAGCATATGACAGTATGTGAATGTCAATTTTGTTGGAGAGTGCTTACCAGTACGCTATAGCTGATAGTCAGGATAACTCTTTCTACTTAATATCAGCCCAAACATCACGGTCCTATTGTGACTTGGCTCACCTAATTTCACCTTGAACAATTGATGCCACTCCTAACAAATTTTTATTTGTGTAATTGAGGAGGATCAGTTATTGCTTCCAGTTTTTGTTGTCAACATAAATAGTAACTATTTGTTATGATGGGCAGATTAGGAAATGGGATGAACCTTGAATTCTTTTGGCCAATATTTATCATTGTTTTCAGTTTGTGGACTGAAGCATAGCCGTGGTTGTTGGGAAAATGTCTTGCTCCTTAAATAATATGATCAATCATTTCCTTTCTTTTCAAAACAGTAATTTTTTGACAGTGAAGAAGTGATCGGATCTATTGAGATGAAAGGAAAGATGATTTCTTGTGCTTTCCTTAGTTATTTCTACACATAAATATTCAGGAATTATGACCAAGCTATCTAAGGAAACTAAATAAATTAAGGAAATAAGGAAACATGCAAATAGAATCAGGATGATATCTGAACATATATAACAGAACTTTTAAACTGTCTTGTACTTTTGGTTAACGATCTATTGAAAAAGACAATTATTAGTGCATCCTTTTTTTGCATGTGTTGGCTCGTACCATTACTCCTTGGGCTGTTGATTTTTAAGCAATGGAAAACATAGTTAGTATTGATTTAACTTTTTTCTTTGCCAAATATTCTAGATTATATTATTTTATGTTTGTTGCTTATGGTTTAAATTTTCCTCTAATATGGAGCCCCAGTTGGGGCTTTCCAAAACTTTCATAACTCTTTGATGCTAAAATATATTTGTTCTGTTGCTCTTCCGGATTGGGAAATACCCATAAGCATTATATGAGTATTTGTTTTTTGTCATAGAATGGTCAAAGTAAGTTTATTAGACCACTTAGTTAAGTTATCATCTACTATCTTCTGTATATCTTGTGTTCAAAGTGCTTCATTATATGGGTTGGTTTCCCTGCAAAGCCCCTATTGCAAAACTCTAAATTAATTGAAGTTCACAGGGTTTGATATTTGATCCCATTATGGTGTCTTTTACAAGTTACTTAAGTGCTAACTGCCCGTTCATTCCTTTTGTTATTTTGTTTATATGTTCTGATTTCCACTGCAGAGATGGATTCTTTTTTGCTGTAAAACAAGTTTCACTACTTGATCAGGGGAATCAGGGAAGGCAAAGTGTATATCAACTGGAACAGGTGAGATGGGATTTCTCTCTTCTCTCTATTGCTTTGGTTTGTGAAAAATGTTTCTTATTTTTGTTTAGTGCTTTTACTTTTAATTACAAAGTAACACCTTGTTTTCATTTTTGTTTATTCTTTCCAAAAGTTGGGATATGAAAGTGGAAGCAACATTTAATTGTTATCTGTTTACATTGTTTCCTGTACAAATTTTGATAATAGGAAAGAAAATGAAAACATAACATTTTGTTGAATCAAATAAATGACCTCAATCATTTTCCATTAATGAAAATCCTTTGCTGAAATGAAAAAGGTTCTCTTACCCAAATATAGTGCTATCTTTTGCAATGCCGTACAATATATTTTTGAGAGTTGATTAACTTTATCAGTTTATTAACCTCATGTCAATATTTTTCTTCTAGATTTCTTTCTCAATTTACTTATCTGTTCCTCTCAGGAAATTGCACTTTTGAGTCAATTTGAACACGAGAATATAGTTCAATACTTTGGCACTGAAATGGTACTTTTCTTAACCTTTCCTTTGTGTTTAGTTTGATACTTTCTTGTCAAGAATCATTGATGAATCTATGCTGATAGTTTCCATCAATTGTATTAAATGTTTAACAGATCAGATACACTGTACTGGTTGTTTTCAGTTTAATGGAGAAATTGTAGCTTGAGTCAGGAATAGAATATATACATGACAGTTTCTACCCCCTGAATGAAAAATGAGAGTATTTGCACGAAATTTTAAATTTAAATGATGTCACTGTAGGCAATAAAATTTCTGATAATATAATATATAATATAATTCAATGGAGATCACTTTTCTTGCATTTGGTTCAACTACCAGGGTGTTGTGGGCCTTTGTGCAATACAAAGTGACAATAACTGAGAACTTGCATTAGGTTATTTGTTGCATGCCAAAACTTTGGATACTGTGGGATTCCATCAATTATTTTCGTTAGTTATGCTACAATACTTTGACTGTATTCAGATTTTGTCAGCTATGAACACTTTTAGCTCTTATATATCTATGTCTGTTTTGAAGGCGTGTAATTTCATGCTGTAATGTAACTGATGTGTTAGAATATAATTAGCTGTTACAGATTTCTAGGAAACTAGGATGATTGATTGATTGATTCCTGATTATTGGTGAAAATTAATTATATTTGATTCTATATGATGCCTAGTGAAATCTGTATTTTGTAATTTTAACTATGTTGTTTATTGCAGGATGCGTCAAATCTGTATATCTTTATTGAGCTTGTAACTAAAGGATCCCTTAGAAATCTCTACCAGACATATACTCTTCGAGATTCTCAAGTATCTGCTTATACAAGGCAGATTTTGCATGGTTTAAAGTATCTCCATGATCGAAACATCGTTCACAGGTCACCTATTTATTCATTTAGTTTTCTTTCCTCTTTGATATAGACAACTTATGGTTTTCTGATAGTCTCAGACAAGAATGAAGTTTATGGCTCTTGTTTACCTTGCATAGGAGAAACTTCCATTTGCTGTCTTATAATTTCTATATAAATATTAAAGGGACTTTTGTTGTATTTGTGTTTCTTTTCTTGTTTTTTAGACTCTCGTTTTGGCCATAGATCTCTTGTTATTACATGTTTTTCTTGTGATAAGGTCGTGCAGAAATTTCAATCGAGACGATCATTTCCCTGTTAGTACTTTAATGGATCCATATATTGGGTAATTGAATAGACTAGAGAGGAGTGGAAGAAAAGTATACAATTAAGAAAATTATTTCTCACCCAACTATTGTCATGGCTATTCTTTTCTTGTCTCAAATTAACACCATTTAGTGCCATTATGTATCCTGATATTTCTGTTGTGGAGTAGCTTTTAAGGATGGATGTTTATATATTATATCAGAATTGCTGGATGTAATTTTTCTCAAGATGTAAAATCGATATTGCACAAGGTTAAGATCGAGAGGTTGAATGATTCACTAAGCAAAGTGTACATGTCACATGTGGGTTTGGTATTGGAAATTTAACTATCAGTGTTTTCTTTTCTGGGGTTGTGCAGTATGCTCATATTTTTTGTAACTGTTTTCTGTATTTCTGTTTCATTAATGTAATGTCATGAAAAATCTTTGTATATATTACCTAATTATTTCCATTGATTATAGGGATATTAAATGTGCAAATATATTGGTGGATGCGAATGGATCTGTTAAGCTTTCAGATTTTGGATTGGCGAAGGTGGCTCTCAGTTCATGACTTTGTTTTGTTCCTGTCGAGCTTCCATTTCTGAACAATCTTCTGTTGTTTGTCTTTCCATTTTCTAATATTGTGTTATTCTTATTGTTTTTCAGGCAATCAAATTGAATGATGTTAAATCATGCAAGGGAACAGCATTCTGGATGGCCCCAGAGGTTTGCCTTCAATATTCTCTTCTAATTAAAGTTATTGAAAAATGGGTATGGGCCGTCATTTGTATGAATGGAGTGTAGACATGGTTGTTAGTAAGTAACAGTTAAAATGTAAGTTTGTTGCTGGATCCATGGTTCTAGATTGAGTTTATACTTTTTTTCAGCCATGGACCTGACACCTATTAAATGAAAGTGATGTCACGCATCTACCAAAAGCAGTATGGATTTAAAATCTTACTGGTCTAAATGCTTGCTTGCTCATTTTGTGAAGTTATTAACTGTCCTACTCAGGATAGAAGGTTATTATTTGTTCATCTGGAAATCCTACCATACAAAATTAACTATGAAATATTGTTTTATGCTCTACGTTTTAATAGAGTTATTTGAAAAGGTGAAACGATGAAACTATTGAGTGTTGCATGAATATCAAATTGTAATATAATAATGGGACCCAACCTGATGATCAGAGAAATGAATCAAAAGTTTGGAGGTATGCAGTGTGGGGAAATAAATAAATGAATCAGGAAGTGAGCACATGACTTTTTGTTTTAGGTTTTCCTTTCTCTGCATGATTGTTATTACGGAAAAGGGTTGTGGTTATGGAGGGGAGGTGTGAAAGGAGAGGACAACTCGTGGTATTCTTGTTGTTTTTTCTTTTAGGATAGGTTTTGGGCGGAGGGTTTCTTCTCTCTAGAACACTTGCTCTATAAGGGGAAGCTATATAGTCTTTCTACAGTTCTCTCATATATCTCTTTGTTCAATAATAGGAGGTACACATTCTATCCATGGTTTATTGGCCTGACTGGCCAATTTCCATAACTACAGCCTCAAGGACAGGGCTTCATTTATAGCAGATAACAAGGATAAGTCCCAAATTGTGAATCTGGGGAGTGGGCCTAAGATTTAAAAAGTGTGCTCTAGAACAAATATGATGGTAAATTAAGTAGGAAGGGACTGTATGACTTATTTTGTTAAGTTATTTTTTTTTTCTTTTTCTGCTTGATTAGAAAAGAGTTGGTGTTGTTAAGAAGCATGGCGAGAGAGTACCTCTTGGCATTCTCATTGTTTTTATCTTTTGGCTTAGGTTTGGACAGAGTTCGTTTTCTTTAGCATTTTGTCTGTGAATGGAGATTATAGTCTTTTTACTTGTAGTAATTCTCTCTTATTTCTCTATTTTTCATGAATACAAGTTACATGTTTCTGATCCTTGGTTTCTATTATCATACAATGTTCTTGACGTAGTGGCAAAGCAGAAATTGATGGGTGGAGATTGTAGTCTTGTTACTTATAGGCCAGCCTATAAATTATTAGCACTGAAACTGAACACCTTTTCTCTTTTCCATTTACATCATAAATCTTGATCAATATAATAAATTGGTGCATATAAGTTGTGTGTGAAACTTGGATATAATTTACTTGAGTGAATTGTTCAAATATATATGGAGAAATCCCTTAAGTTTTAGGATTGAAATCAGTGTCAGCATAAACTATTTAAAGAACTATGCACACATGAAAGAATAAAATGAAAACAAGACTAATTAACAAGTAATTAAAATTAACTCAATCAATTGTAGGTAGTTAAGCCTGTTTTCAAGGATTCATTACTGCTTCATGAATGAAAAGAATTTGAAACAAGAAACTTTGCCCTTGAGTTTGGATGGGGTATTCTAAGAGAATACTTCATTGTTTTTAGTCAATTTAAAATGTTATTTGGATAGTAAATTTAAAAAGAAATTGAAATTCTAAAAATTTTAAAAAATATTTTGATTACTTGAAATTGTAGAATTTAAAATTCTACAAAAAGAAAGTTTGAAATTCTTCATGTTCTCTCTTCTTTTTAACTTTATGTCTCTTCTCTTTCCTCATTCTCTTCTCTATCCTTTGTTTCTCTCCTCTCTCGTTGTTCTTTCTTACTCTCCTGTTTCCTATCTCAATCTTCTCTCTTCTTTCTAATTTTGAATAATTAAATATTATGATATGATAATATTTTGTTGAATTATTAAACATTAATTACTTTTTTCATAAAGTTTAATATTAAAATCAGTTTCTAAAGATATATTAATTTTTTTTGCATATAATATATATTAAATTGTTCTATCCAAATTAAGAGTTTGAAGTTTAAGAAACTTGAATTGATTTATCTAAAAATATTTAAACGATGAAAGAAATTTAAATCAAAGCCATCCAAATTTCATCAGCTTCCTTAGTGCCCAATACATGGATAGAAAAGAAACTTTTCAATAGCAAAAAGTCCATCTTTTCGGATATATAATCTGATTTCTTATTTGCATAGTTAGAGGTTATTAAGCTGTATTGTTCTAACATGCAGGTTGTGAAAGGTAAACAAAAAGGTTACGGGCTTCCAGCTGATATATGGAGTCTTGGATGTACTGTGTTAGAGATGTTAACTGGCCAATTTCCATACTCTCACTTAGAATGTGTATGTATTACTACTTCCGTCATCACCATTTCCTGTATATTGATTTTAATTGAGCTTGTTTGGTAGAGAAGAAATGATGGGAGATTAAAATAAATAGTAATGTGTGCTTTTAAAAAGTCATTTTGCTAAGCAACCATGTAAATTTAAAATATTTAATTTTGACCATTCGAGTACGATTGTAGATCTTAAATGTGTTTCTAAGTCTTAAATAAAAAATTACTTTCTTATTAATACATTCCCTATGTATGTGTGTGAGTGTCGTTGCATTTCTGCTGGTTTTGACTTGAGTTTTTGATGAATCTCTCTGGACAACAGATGCAGGCATTGTTTAGAATTGGAAGAGGCGAGCCCCCTATTGTGCCCGATTCCCTTTCAAGAGATGCACAAGATTTTATCCTGCAGTGTCTCAAAGTTAATCCAGATGAACGTCCCAGTGCTGCTAAACTCCTAAACCATACCTTTGTCCAAAGGCCGCTACTTTCCCAGACCTCTGGTTCTGCATCTCCTTATATTCGAAGGGGTTAAAATTGTCACCTCCAACTATGAAACATAATGAAGGTACATATTGTTACATAACATAAACATCTCATTTTTCTTCCATATTTATCTTATTTTGCCATGATTTGTATATATTGAAAATCATGGTCATGGCTGTCTATCCTTTCACTAAGGCTCTGTTTAGAAGAGAAGAGAGAATGGAGTGAATGAAAATAGTGATACGTGGAGATAGGTAGAAATAAAGTGAATCTAAAGGTGTTTGGTTGAAAGAAATAGAGAACAAATTATGAGAGATAGGGAGAAGAGTCGAAATTGGTAAAAGCAAAGTGAATAAGAACTGGTGGGACCCACTCACTTTTATTTTCTCTCTTCCCTCTATTTCTTTTCTACCCAAGAATCTCGATTAAATTCATTCTTTGTATTTTCACTCTTACTCTTGCACCTCCTCCAACCAGACCGTAAGTTTCAATACTAACATAACTGATGACAAATTTGGAATGGAAACGATTTAAAATGTTACTTTCAATCGGATTGGATGCATATATAATTCAAACAAGCCTTCGGTTAAGTTAGGTAGGGTTTAAATGTGTCATTCTGCTAGGATGGACCAATAGAGGTCCAAAAGAAAGAAAATTAAGCAATTTAAAGATTTCAGAATGGTCTTAGAATATTAAAAATAATCTTTTTAATATTTAGTTTATATTTTTATTCCTTTAAGTAAGACGATGACACTTGTTGGGTGATCATTTAGTTGTTGGTATATTTTAGGTTATATAAGTCAGTCCCCGTGGTTCTCCACTCAATCCCAATCTTCTAGTCGCCAAGCACTTCGTCAGTTGCCATGGCAGTCACAACTGACTTTCCCTTTGTACCCATATGGGTTTGGATTCTGAACAACGAGTTTCGAACCCATATACTTTAATCCTCTCTTCCGCTCTCAATGTTTATCCATTAGTTTCTGCTTCAACCACTTACCACAATACCCATTTTGCAGTACCTTCTACAACCCTTACCCTGGCGTGGATAAATCTCACAGAAAAAGAGAGTTTGATGGAAAAGCTCTCATAGAAACAAAGTTGATGGTACCAAAGATTTCAGTAAAACCCGAACAAGTCATGGAGACACCCATGGAAGCAGTGAACACAGGGAGATTTTATCAGAGATCCACCTCCAATATCTAATAATGAGTAATATTTGGCAAAGTATTTCCCTATCAATTCATATCTCTTACCTCTCAAGCTGTGGAACATATGTATGATACAAACTTGTTACAAATATCATCCACACAACACCCTTATGGAGACTAGTAAAGATGTCAGCTGGCAGTTGGTTGCCAAAGTTCACAGTAAATAATGACAGCGTAGATATTTTCGGGACATAAACTTTCTCTGTCAAAGTTATATTATATGCTTCGTCCTTTCAAATCATATTTTTAATATTTCCCTTCAAGTTGGAACATAATGGGTCAAGCTCGTTAAGAATGGTCAAAGGATATGATGACTGTCAAAGAGCAAATATGGGTAGTTGACTTGACAACTGTTGGAAGGCAAAAATGATAAGAGGATGCGGTAGTTGTTGGATGGAAAAAATGATTAGTGGTTGCGGTCGCTGTTGAACAGCAAAAATGATTAGAGGATGCGGTGGCTGTTAGAAAGCAACCCAGAGAACATGGTGGCTTTCAGAAAGCAAAAGTGTTCAGAGGACACAGTAATTATCAGAAAGAAAAAATGTTCAGAGGAACAACGGTTGTTGGAAAGTAAAAAATGGTCATCGTACAAGGCAATGTAGAAATGGCAATTGCTGTCTGGAAAAAAACTGGTCAAAAACCAGAAAGAAACATGTCAGGAAAATGTTGGCAGTGAATGGTCATGTCGACTGGAGAAACCTTGATGATAAAGAAACTTGCTGGAAAATATCGGTAACGTTCATTGGTGGTAAACTATACTTGCTGGAATAAGTCGATGGTAAATAGAAACTGTTGGAAAAAAGCTGGTGGTAAACAGTACTTGCTAGAAAAATGTCGGGCAGTAAGAATTACTTGTCGGAAGATGTCTGTGGTAAATAGTATCCACCGGAATAATGTCAATGGTAAACAGTTACGTCCAGAAGGAGCAAATCCAAAAGTTGTTTGCAGTGAATAGCAATGCCAACAGTTAACTGTGATACAATGTATCTTGTGGGAACAGTGACAACCAGGAAAAAACATAAAGCAAAAAACATAAACGGTTTTTAAAATATTTACTCCTGCGCGTAGGGGGCACTCAGGGAAAGTACGGATTTGAGTTCCCTTCTCGTTAAGCTCTTAATACCATTTTTAAAGCTCTAGTGACAAAACAGGTCATGGAGAATGGTACTGTTTGGATACCATTTTGATAGAAACCGTGAAGGAATATGATGAATTTTGTGTTGGGTACACATGGATATTCTTATTTATAATGAAGAAATACAATAATAAGATATTTCCTTACCAAATCATTTCATATTGCTATTTAATGTAATCAACTTATGTCTCTAGCATAATGAACTCACCCTTCAATCTCCTTCCTTAGCCAAAGGCTTAATATGTGTGCTTAACCAAAATTGTCCCAGGACACATAACACTACATTTTCCCAATCACAATTGTTGGACACAAATCTTCACACGACCACCTATTCCCACGGGCAACTTAATGCAATTTTCAAGGACCTTGAGGACAAGGCCCAATGGGAATGGTTGGATGATGATAGGATGGGCGAAAAGAGGCCCAAAAGAAAGAAAATTAAGGGGCTTAAGATTTTATATTATGCTCTTATGATATTAAAAATAATATGGGTGTTGCTCCCTCCACCACCCCAAGTGCTCCTGCACCTTCCCACTATTTTCTTTTATTCCAAAAATACTCTACACATTCCCACTATTTTCTTTTATTCCAAAAATACTCTACACATTCCCATTATTTTCTTTTATTCCAAAAATACCCTACACCTTCCCATTATATTCAACAATCTTTCTCTTTCTCTTTCCACATTAATGGAGCATTCACATGGCTCGAATTTAAACTTGTATATTGCAAAATTTTATTTATACTTTCTCTTAAATAGTTTGATTCTATCTTATTTTCACTGTTCAATATATTTTTTTTCCTTCAAATTACTTAATAAATGGTTCTAAATTTCTAGAAAAATGTTTATATATATGTGTTTTTTTTTACATTTAATATCTATAATTTTTAACATTATATTATGTTTTAACTTACCGACATGTTTGACTCAAATAACTTGAATAAAGTATTTGATTTATTAGTAAATAATATAAAAATATTATTAAATACTTAAAATATTAAAGAAAAGTTATTTGTTAAAGATTTGAAATTTATTTAGTTCTTTTGTCATTATAAAGTTAATATATAATAATAATATATTATTTACTATTAATATTGTTATGTTTATTATTTTGTATTTGCATCTAACTTTTAAGTTTATAAAATGGAAGTGGTAGAAGCACTAATATTGAAGTTTCTTCTGAATTTTATATTTTGCAATATATCACAAGTTTAAATCTAAGCCACTTCATTAATGCAGAGAGAGAAAGAGAAAGATTGTTGAGGATAGTGGGGAGGTGTAGGGTATTTTTGGAATAAAAGAAAACAGTTGGGAGGTGTAGAGTATTTTTGGAATAAAAAAAAATAGTGGAGAGGTGTAAAAACAGTTGGGATGGTGGAGGGAGCAACACCCAAATAATATTTATAACATTATTAGTTTATATTTTTATTCCCTAAAGGAAGATGATGACACTTCTGGTCATCATTTAGTTGTCAGTATATTTTAGGTTATATAACTGGATTATTCCTTTCCTATTATCATCTGGGAAATGTCATTGTTTATTTTTATCTTTATAACTTTATTGGTAGATTCTCATGCAAATATTTGATTTGTGAAATAAGAGGAAAGGGAAGAGGAGCAAAACCTTTCTTACCGGTTTCATGTAAATTTTCATTTTAGCATGGTTTGATTTTTCTTCTCTGACTTATTTGATTTTTTTTTCCTTTTAAGACAGATCTGTCGCTCATTGGATATAAGATATCTCCAAATGTTCAGTCTTCAAGTTGCTAGAGTTGGTCCGGGGTGCATTGTTGTAGCAATAGTTCGTTGTATTATGCCTTCAGAATTCACAGTTTGCTGCTTGTATGTTTACTCAATTTTTAAAGCACTGCATTGGATCTAGCAATTGATATGGCACTCCAGAGAGATAATTTAACCTACGGCTTGAAGAATACCATATTTAAGAATTATGGTCCACGTGTTATTAATTACTGTGATTATTTGTCTGTTGTATAAGCCTAAAATATCAACGTCAAGCTGTAAAAGGTTGTCTGAGTCTAACCCTTTTGTTTAGTTAGCTAATGAAACAATTCGTAGGCTAAACCACCGGGAGCACTACTTGTAAGGATTGGATACCATGCTGTTTTGTATATATCACCTTTATTGGTAAGCAATTAGTTGTATACATCCTTATTTTGTTCCC