Gene Details:

Gene ID Chr. No. Start Position End Position Function View on
Vu_22825 LG5 59423836 59429249 PREDICTED: mitogen-activated protein kinase kinase kinase ANP1
Map

Annotations  
category   relationship type   keyword
Biological Process   involved in   protein phosphorylation, protein autophosphorylation, response to oxidative stress, protein phosphorylation, flower development, protein phosphorylation, MAPK cascade, protein autophosphorylation, protein autophosphorylation
Cellular Component   located in   cytoplasm, nucleus
Molecular Function   enables   protein kinase activity, MAP kinase kinase kinase activity, MAP kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase activity, MAP kinase kinase kinase activity, protein kinase activity
Pathway   B 09132 Signal transduction   C 04016 MAPK signaling pathway - plant [PATH:ko04016]
SNP Position Effect Amino acid change
T/A 59424211 intron_variant
T/A 59424365 intron_variant
T/A 59424382 splice_region_variant&intron_variant
G/A 59424477 intron_variant
A/G 59424509 intron_variant
C/T 59424603 intron_variant
C/T 59424627 intron_variant
A/G 59424710 intron_variant
T/A 59424722 intron_variant
C/T 59424744 intron_variant
G/A 59424859 intron_variant
G/A 59424924 splice_region_variant&intron_variant
G/A 59425315 synonymous_variant p.Gly207Gly
G/A 59425382 intron_variant
T/C 59425541 synonymous_variant p.Thr247Thr
G/T 59425918 intron_variant
T/A 59426063 downstream_gene_variant
C/A,T 59426362 downstream_gene_variant
A/C 59426363 downstream_gene_variant
G/T 59426440 downstream_gene_variant
C/T 59426498 downstream_gene_variant
G/A 59426696 missense_variant p.Arg319Gln
A/T 59426720 splice_region_variant&intron_variant
A/G 59426773 downstream_gene_variant
C/T 59426826 downstream_gene_variant
G/A 59426845 downstream_gene_variant
C/G 59427006 downstream_gene_variant
C/G 59427027 downstream_gene_variant
C/A,* 59427194 downstream_gene_variant
G/A 59427197 downstream_gene_variant
A/G 59427330 stop_retained_variant p.Ter388Ter
C/A 59427351 missense_variant p.Ser395Tyr
A/G 59427369 missense_variant p.Asn401Ser
T/A 59427370 missense_variant p.Asn401Lys
G/C 59427602 missense_variant p.Asp454His
G/A 59427613 synonymous_variant p.Gln457Gln
G/A 59427635 missense_variant p.Val465Ile
T/A 59427636 missense_variant p.Val465Asp
A/T 59427683 stop_gained p.Lys481*
A/G 59427750 downstream_gene_variant
C/T 59427872 synonymous_variant p.Ser509Ser
A/T 59428058 synonymous_variant p.Thr571Thr
G/A 59428153 downstream_gene_variant
C/A 59428318 downstream_gene_variant
G/A 59428373 downstream_gene_variant
A/G 59428378 downstream_gene_variant
G/T 59428444 downstream_gene_variant
A/G 59428577 downstream_gene_variant
T/C 59428674 downstream_gene_variant
A/G 59428687 downstream_gene_variant
C/A 59429026 downstream_gene_variant
A/T 59429148 missense_variant&splice_region_variant p.Asn621Ile
G/T 59429215 missense_variant p.Glu643Asp

View accession wise SNPs


Sequence Details:

Protein Sequence:
>Vu_22825.1
MQDIFGSVRRSLVFRGSPESDETSLGVGGSLVDKISYCIRTSRVFSKPSPPSPSPSIPEDAAPPIRWRKGELIGCGAFGQVYVGMNIDSGELLAVKQVLIAASSASKEKAQAHIKELEEEVKLLKDLSHPNIVRYLGTVREEDTLNILLEFVPGGSISSLLGKFGAFPEAVIRTYTKQLLLGLEYLHKNGIMHRDIKGANILVDNKGCIKLADFGASKQVVELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSQQYQQEVAVLFHIGTTKSHPPIPDHLSAAAKDFLLKCLQKEPVLRSSASELLQHPFVTGEHMTSLTLSSNVTENFIASSPSCTPNDESILCSSTVNPLDSGNKQLWGMSNDDDDMCVIDDKEEFSHNDVKYKSLMSTDIESFNPMSDPSDDWGCKFDASSELENREVNFVTDENYMPPDQSGDDKGQPDFSFPGVPSLSEEDDELTESKIKAFLDEKALELKKLQTPLYEEFYNSLNTSCSPNVDRTSDDTASRNFLKLPPKSRSPNRVPISTPSKAIDNTGSPGSNGQSSSTVGHVNNHTSQDIPASPLNEWKGVIVDSQQQPSSPSLSFSERQRKWKEELDQELERKREMMRQAGMGGKTSSPKDRALHRQRERTRFASPSK*


CDS Sequence:
>Vu_22825.1
ATGCAAGACATTTTCGGATCAGTTCGCAGATCACTGGTATTCCGCGGTTCGCCGGAGAGCGATGAGACCTCGCTCGGAGTCGGAGGAAGCCTCGTCGATAAGATCAGTTATTGTATACGAACTTCCAGAGTCTTCTCCAAACCCTCGCCGCCGTCGCCTTCGCCGTCTATTCCTGAGGACGCTGCGCCTCCGATCCGATGGCGGAAAGGCGAGTTGATCGGTTGCGGTGCCTTTGGCCAAGTCTACGTTGGAATGAATATCGATTCCGGAGAGCTTCTGGCGGTTAAACAGGTTTTGATTGCGGCGAGTAGTGCTTCGAAGGAGAAGGCACAGGCTCACATAAAAGAGCTAGAAGAAGAAGTTAAATTACTTAAAGACCTTTCTCATCCAAACATTGTTAGATATTTGGGTACGGTCAGAGAAGAGGACACCCTAAATATTCTCTTGGAGTTTGTTCCAGGTGGATCCATATCATCGCTGTTGGGGAAGTTTGGGGCTTTCCCTGAGGCTGTAATAAGAACCTACACGAAGCAGCTACTACTTGGACTTGAATACTTGCACAAAAATGGAATCATGCACAGAGACATTAAGGGGGCCAATATTCTGGTAGATAATAAAGGGTGCATAAAACTTGCAGACTTTGGGGCATCCAAACAGGTCGTTGAGCTGGCAACCATTTCCGGGGCCAAGTCCATGAAGGGTACTCCATATTGGATGGCTCCAGAAGTTATTCTCCAGACTGGGCATAGCTTCTCTGCTGACATATGGAGTGTGGGTTGTACCGTGATTGAGATGGCCACTGGAAAGCCTCCCTGGAGTCAGCAATACCAACAAGAGGTTGCTGTTCTCTTCCATATAGGGACAACTAAGTCTCATCCACCAATCCCTGATCATCTTTCTGCTGCAGCAAAAGATTTTCTGCTAAAATGTTTGCAGAAGGAACCGGTCTTGAGGTCATCGGCATCAGAACTGCTGCAGCATCCCTTTGTAACTGGTGAACATATGACTTCTCTTACTTTGTCATCTAATGTCACGGAAAATTTTATAGCTTCATCACCATCATGTACCCCAAATGATGAATCCATCCTTTGCTCTTCAACAGTAAATCCTCTGGACTCGGGAAATAAACAATTGTGGGGAATGAGCAATGATGATGATGATATGTGTGTAATTGACGACAAAGAAGAGTTCTCGCATAATGATGTTAAATACAAATCACTGATGTCAACTGATATTGAGAGTTTCAACCCAATGTCTGATCCCTCTGATGATTGGGGGTGTAAATTTGATGCAAGTTCAGAACTGGAAAATCGAGAGGTCAATTTTGTCACAGATGAAAATTACATGCCACCTGATCAGTCAGGGGATGATAAGGGGCAGCCAGATTTTTCCTTTCCAGGTGTCCCATCTCTTTCAGAGGAAGATGATGAACTCACAGAGTCAAAAATCAAAGCCTTTTTGGATGAGAAGGCTCTTGAACTGAAAAAGCTACAGACACCTTTATATGAAGAGTTTTACAACAGTTTAAATACATCCTGTTCTCCCAATGTTGACAGGACAAGTGATGATACTGCTTCTCGAAATTTTTTGAAATTACCTCCTAAAAGCAGGTCACCTAATCGAGTACCAATCAGCACACCATCTAAAGCCATCGATAATACTGGAAGTCCTGGAAGTAATGGCCAGTCCTCATCTACTGTTGGCCATGTAAATAACCATACATCTCAGGATATTCCAGCATCTCCCCTTAATGAATGGAAAGGAGTGATAGTTGACTCTCAGCAGCAGCCTAGTAGCCCAAGTCTAAGCTTTTCTGAGAGACAGAGGAAATGGAAAGAAGAGCTTGACCAGGAGCTTGAGAGAAAGCGAGAAATGATGCGTCAGGCTGGCATGGGCGGAAAGACATCTTCACCAAAGGATCGAGCTTTACATCGGCAGAGGGAGCGAACAAGATTTGCTTCTCCCAGCAAATAA


Promoter Sequence:
>Vu_22825::LG5:59421836-59423836(+)
GGTATACTATAGTCTTTGAGTTAGAAACGATTAGAGATTGACCTCATTTAGGTATATTGGATATATAATTTTGTATGTTAGGTTAGAAGCTAAAATTGTGTACTTGAATTGCTTGGGTTTTGTTGATTGGTTATTAGTGAGAATTTCTTTGTGAGATATCAAATTGATCAAAGTGATGTTTCCTGGTGTTGAAACAAAGTTATATTGTATTAGAATGAAACGTAATAAGCAATGAAAAAGCTCAGAAAAATCCAAATTGATAAATCAAATCTCGCAAAGAAACTCAACCTTTTTGATGTAGCATTGGACGTTCCTACAACATCGCTATGCGCTAATCAAATAGTGTTTCCTTGTCGAACTAAATATAATCTTAGTACATTTGGGCGCAAAAGTGATAGTGAACTTATTGTTTTGTTAGTGTTGAGTGCCACCCATGGATTGTTAGATGCAATTTGGAATTTAAAATTCAAAAATAACTTTAGGGATTTGGACACTATTATAGTTTTGTTGAACAACAAAAAGGTGTTGAGCGCCCTTGGTTGCGTTAAGTACAATTTCTATTAATAAAATAATTTTCAAGAATAAAAACAGATGTTTTTCACAACTTTGTTTTTCATCAATATAATACAATTCACATTACATATAAAAATATAAACATAAAATTTTCATTTATACATAACCAACATAGAACCAAATAAAAATTACCTATAGATGAGATTTTTCTTTTCTGCCTCACTCACTTAAGCAAAAGACATCAAAAACAAACCTTTTGTTTTATTTTAATTTAAGAAAAAATCTCTCACTTCAACAAAAATAAAATAAAAACAAATGTTTGAAAAAAAATTTCAAACCACTTTACAATGCACAACATCAATCCAAAATAGCTTACAATATTTTCAACAAGATACAAATACTATCATACAATTACTTTATATTTATAAACATCAATAATTTGTTTCTAACTCACAGAGACTACTTCTAACTCTAATTGGTTTCCTATGATTTAAGTGCAAAATCCAAACAAAACTAAGATACCAATTTATTCAAAGTTTTACCAAATTATTAAATTCATAAATTTCTACTTCCAACCTCAATATCAATTCAAGACTCAAGCAAATGAAAGTAGCTAAACTCTATTAATCTTTTACGGAGAAAATATGACAAATTATATCAAACTTAAAAAAAAAAATAGAGAGAATTATGATAATTTTTGAGGGAAATAAAAATATAAAATTGGAATGGGAGGTTATTGGGCCTCTTTGATGCTTATAACTAATGATGGCATGAAAACTTTAGGCTTTCAAATTCAATCACGTATCTGCTAAAATTATATTCAATTGATCCTCTAATGCTGTTCCTCTTGGTGCCATACACGGCCCGAAATTTTGGGCCTTTTCCTTATAAAAATTTATTATCAATTAAAAGAAAGTGATTGTTGGCGTTTTTAGATACTTATTATTTAAGTTGCTTACATAATTGAAATCTGTTATTGTGTTTAGCTATCATTTCAGACTTATTTTGATTATTTATGCAAAACAGGCAACTAATATTTGTTAGAGTGAAATAATAATTTTCAATTATTTCTGTTAAAAGCACATTTCTGGGGTGAATTCCAAAGACGAAAAAGAAACCAACATGAAGCAGTAAAATTCTAAAATTAGAGAATAATAATGATGAGTTCAACAAGGGGTGGACTTGGTGTACGTGAAAAGGGGTGAAAGCTGAAAAGGAAATTGAAGTGTTTGTTTCACGTTAAGCAACAAGTCCAAAAAAACTGAAAAATTAGCAAAACAGCCCCAAACATTAGTTTTATTATATTCCAAAATCACCCAAAATTTGAAGTTGGTGTCCCCTTTCCCTTTTCCCTCTATTCTCTCCTTTGTATTTGTATAGTTCAGTTCTGTGGTTGCCGACGCAACGTCTATCGCACACACGCATCGCTCTTCACTCTCTCACTCTCTCACTCTCACTCTCACGGAGAACGCCAGAAAGATCGCAAA


Gene Sequence:
>Vu_22825(+)
ATGCAAGACATTTTCGGATCAGTTCGCAGATCACTGGTATTCCGCGGTTCGCCGGAGAGCGATGAGACCTCGCTCGGAGTCGGAGGAAGCCTCGTCGATAAGATCAGTTATTGTATACGAACTTCCAGAGTCTTCTCCAAACCCTCGCCGCCGTCGCCTTCGCCGTCTATTCCTGAGGACGCTGCGCCTCCGATCCGATGGCGGAAAGGCGAGTTGATCGGTTGCGGTGCCTTTGGCCAAGTCTACGTTGGAATGAATATCGATTCCGGAGAGCTTCTGGCGGTTAAACAGGTCAATTACTTTCTCCGTCCTTTGTTCGTTGTTGACTTCATCGTTAATTTATGCTTTCTAGTTTATCTTCGTTTAGAATAGTTTTTTTTTTTTTTTTTTGGAGTTCAGTTCTTAGCATCTGCTTGTTTATTCTTTTTCGTTTCATTCTTTATTAGAATTGGCTTTGTTAGGTGAGTCTGTCATTGCGATCCTCAATAAGTTGAAATTAATGTGGTTATAGCTTTATCGCTAATTGATTTCGTTTTCTGCTCTGGTTTTTAGGTTTTGATTGCGGCGAGTAGTGCTTCGAAGGAGAAGGCACAGGTTTGTTGTCTGATCAAATCCCATTCGCAACTACTTCTGATTTCATCGACTAAAGCCAGCCAATTGTTGTAACTTGCATATTATAGACGTTTGTTAGTTGTTTATACAGTTCTAAATGATAAACCGGATCGTTGTAACTTATAGATGTTTGATCTTTCCTTTTCGGTTAGTTGCTACATTTTTCTTTTCACTAAAGGCATTACGTATATTTTTTCATCTGAATTTTCCTTTTTGCTGTTAGCTGTTACAATTTTCTTTTCTAGAGAGGCATTACTATTTTATTTTGTCATATTTGTTTTTTCCTTATGCGGTTCCTTAATTAATGTTTTGATATACTACTAACAGGCTCACATAAAAGAGCTAGAAGAAGAAGTTAAATTACTTAAAGACCTTTCTCATCCAAACATTGTTGTGAGTATGATATTCTATGGATGAAAGACACTTCAGGCAAATTTAGTTCAGACGACTATTTCTTGACTGTATATTTTTATGCTGCAGAGATATTTGGGTACGGTCAGAGAAGAGGACACCCTAAATATTCTCTTGGAGTTTGTTCCAGGTGGATCCATATCATCGCTGTTGGGGAAGTTTGGGGCTTTCCCTGAGGCTGTAAGTTTTAGTTACTGAGCTGCTATACTTTTTTTTTTTTTAAATTGTTTTTTGTAATCTAAATCAATTCAACTAATTCATTCAACAGGTAATAAGAACCTACACGAAGCAGCTACTACTTGGACTTGAATACTTGCACAAAAATGGAATCATGCACAGAGACATTAAGGTGAATTATATTTCACTGATACTCATGTTATCTTGGTTCTTATCTGGTGGCTGATGTTCAAGTTGTAATTAATTTCAGGGGGCCAATATTCTGGTAGATAATAAAGGGTGCATAAAACTTGCAGACTTTGGGGCATCCAAACAGGTCGTTGAGCTGGTAATCTCAGTCTTATCTGTTGCTCTACTATTATTTATATTGCTTTACCTTTGTGAGGCTTCTTCTGTTTGAAAATTTGTTTAAGCAGTGTTTTTTCTTTATCTAGGCAACCATTTCCGGGGCCAAGTCCATGAAGGGTACTCCATATTGGATGGCTCCAGAAGTTATTCTCCAGACTGGGCATAGCTTGTAAGGACATTAAATCTCTAGACATATTTTAACATGTTATTCTGTTATTAGTATGGTTTAACGTGATTGAGAAACCGAAAGTTTCTTCTGGTTAGATATCACTTGCTATCATAGTTGTGACTGATTGTTTACAATTCCAGGTGTCTACCATTCTGTGTATCAAGTTGTCTTACAATTTCCTGCCTTAAATATACAATGATGGTTTCTGTTAGAAATAGAAACCTTTGGTTGAGATATTGAAGAAGTTAGTGGCAGGAATTTTCAGCAAGATACATAGGCTAAATATGCTTTTAAAGTTTCTAGTCCTAAGCAATTTGAAGCAGAGTCATAATTGCTTTCGTCTCAGTTGTCATGTCTTGAAGAAAGAGTTGTATGTTTTAGAAACTGATTCTACCTTTGAAATTCTACTAGGAGATTCTTATATACTGTTCTTGGTGTATTTCTTGAATTTTATTTTGTTTAGTTCTTTTCTGCAATTGTATAATATATCTTTTTGAAATGGTGTTTCATTTGATGTTAACTAAATAAAAACGTTTTCATTTCAGCTCTGCTGACATATGGAGTGTGGGTTGTACCGTGATTGAGATGGCCACTGGAAAGCCTCCCTGGAGTCAGCAATACCAACAAGAGGTATCTCATTATGAGTCCTTAAATTATGCTTAAGGTTCTCTCTGAATCTACTAAAAGACAAAACTTTCAGGTTGCTGTTCTCTTCCATATAGGGACAACTAAGTCTCATCCACCAATCCCTGATCATCTTTCTGCTGCAGCAAAAGATTTTCTGCTAAAATGTTTGCAGAAGTAGGTTTCATCTGCTTCTCTTGCATTACAAATTCCTAGTTTTAGTGTGTTTCTTTGTGATTAATACTTGTCTCAAAGCATATGATGGAAGATTGATCAACTAAACATTATTGAGTTTTTATTTTTTTGGTGGGTGGAGCGGGGCGTGGAGGGGGTATGGGGAGAAAGATCCATCAGCACATTTCTATATTAAAAGTGACTTAACTTTCAATGTGTGCGTTGTGTGTAAAAGAGAGAATATATGCCTAGTATGCTTTTTTTTTTTTTCAAAGTTTGTTTATCAGATTACAAAAATCATGTAAATTTATAATCTTTTTGTAGGGAACCGGTCTTGAGGTCATCGGCATCAGAACTGCTGCAGGTGATACTTCAAGCATCTCTTTTAGACTGCGCATCTGAAGTGTATAATATTTTTGTGTAGCCATTTTAGTAATATTGATTGGTAGAAGACTCTACTTTTTTATTCTTATTGCTGCTGTTAACAGTGTTTTGCATGAAATATTTCAGCTCTCCCTAACATTATTTTAAGTTTGTAACTGACTGCAGCATCCCTTTGTAACTGGTGAACATATGACTTCTCTTACTTTGTCATCTAATGTCACGGTATGTAAAATTGATGTGATATTTGAAAGGCTATTGTATCTTTTACAAACCAATTTTTAAGAAAAAATTGCTTTCACTGCTGACAGGAAAATTTTATAGCTTCATCACCATCATGTACCCCAAATGATGAATCCATGTAAGTGTTGAATATTTCCTTCAAGGACTTGTAAGATTTGGTAGTTATTTATGTGGAGCATATAATGGAGCTATAATTTCAATATTATATTTTTCTTGATGCTAGTGAATGGCAATATGGTTTTATTTAGCAATTTTTTTGTAATTTATGTAGCCTTTGCTCTTCAACAGTAAATCCTCTGGACTCGGGAAATAAACAATTGTGGGGAATGAGCAATGATGATGATGATATGTGTGTAATTGACGACAAAGAAGAGTTCTCGCATAATGATGTTAAATACAAATCACTGATGTCAACTGATATTGAGGTGATTGTAGGTCCTTATTGTTTTATTTAAATATGAAATTAATGACTTCTCAGACACATTTTATTTCATGTAGAGTTTCAACCCAATGTCTGATCCCTCTGATGATTGGGGGTGTAAATTTGATGCAAGTTCAGAACTGGAAAATCGAGAGGTCAATTTTGTCACAGATGAAAATTACATGCCACCTGATCAGTCAGGGGATGATAAGGGGCAGCCAGATTTTTCCTTTCCAGGTGTCCCATCTCTTTCAGAGGAAGATGATGAACTCACAGAGTCAAAAATCAAAGCCTTTTTGGATGAGAAGGTATTGCTTTTTGTTGAAATCAAGTTTGTCGTTTCGCTGTAAATTCATCAATTTTTTTGTGTACTAACTGTTGTGTCATATGTTGATCATACATTTATGACAGGCTCTTGAACTGAAAAAGCTACAGACACCTTTATATGAAGAGTTTTACAACAGTTTAAATACATCCTGTTCTCCCAATGTTGACAGGACAAGTGATGATACTGCTTCTCGAAATTTTTTGAAATTACCTCCTAAAAGCAGGTCACCTAATCGAGTACCAATCAGCACACCATCTAAAGCCATCGATAATACTGGAAGTCCTGGAAGTAATGGCCAGTCCTCATCTACTGTTGGCCATGTAAATAACCATACATCTCAGGATATTCCAGCATCTCCCCTTAATGAATGGAAAGGAGTGATAGTTGACTCTCAGCAGCAGCCTAGTAGCCCAAGGTTTGTTTGTTTTTGCCTTGCCTTGCTTTTCTAAGCTTGAATTGTTTTCAGAAATATAAAGTAATTTAAGCACTGTATGTTGTACTTGCAGTCTAAGCTTTTCTGAGAGACAGAGGAAATGGAAAGAAGAGCTTGACCAGGAGCTTGAGAGAAAGCGAGGTTCGAAATCTTTTTACTAACATAACTAATAAGTTTCTATAATTCCTGATTTTGCAACCGTCATTAAGTTTGGCTGTATTAGTTAATTCGATCCTTAAGTTTAGTACATATTTAGTCAATTTAATTTAATACATAATATCTAGTACGAAGTCAATTGATTTAGTTAAATTGAAGTATCAAAGTGACCATAATTGTCAAATAGTTACTAAATTGACTAATTTGATGTGTTAATTTGAATAATCAAATTAATTGATAAGTATCCAATAGACGAAATTGCCAAATTTTGGTATTAGATTGACTAATTTGGAACCAAATTGACTAATTTGGAACCAAATTGACTAATTTGATAATGAATGAACCAAATTGGCGCTGTCAATTTCAACAGTCAAATTAATTGATAATTATTTATTACAGTCAATAAAATCTCCTTTTTTGTAATATCAGGGATCAAATTGAGCAACGATGCTAGTTTTAAGGATGAAATTATAATGCTGGAACCAAATTGAAAGTGTCAATTCCAAGAATCAAATTAGTTGATATTTATTACAATTAAACAAGATCGTTTTCCTTGTAATACCCGAGACCAAACCATGATGTTAATGTTAAGGATTAAGTTTATAATTTAGAACTCTTACTCAATTTGACTGTTATGTAAGCGAGAGACACGAACAGAGAATTCAAAGTTGTCATTGTCTTCAACATTCTTTCTCATGAGCAGAGAATGCTAGCGACTCTCTCACATTCCTTCTAAAAATCGTACTTTATTCTTAACACAATTAAAACATAATATGTTAGCTGAATTTGGTAGGATTCATTAATTTACAAGTTGATTTGGACAAATATTGCAGAAATGATGCGTCAGGCTGGCATGGGCGGAAAGACATCTTCACCAAAGGATCGAGCTTTACATCGGCAGAGGGAGCGAACAAGATTTGCTTCTCCCAGCAAATAA