Gene Details:

Gene ID Chr. No. Start Position End Position Function View on
Vu_33663 LG9 47290991 47304383 serine/threonine-protein kinase PBS1
Map

Annotations  
category   relationship type   keyword
Biological Process   involved in   negative regulation of cellular process, protein phosphorylation, protein phosphorylation, plant epidermis development, protein phosphorylation, inorganic ion homeostasis
Cellular Component   is active in   plasma membrane
Cellular Component   located in   plasma membrane, plasmodesma
Molecular Function   enables   protein binding, transmembrane receptor protein tyrosine kinase activity, kinase activity, transmembrane receptor protein tyrosine kinase activity, protein binding, transmembrane receptor protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, ATP binding, ATP binding, protein binding
SNP Position Effect Amino acid change
G/A 47291785 intron_variant
T/A 47291792 intron_variant
T/C 47291799 intron_variant
T/A 47291848 intron_variant
T/A 47291864 intron_variant
C/A 47291899 intron_variant
T/A 47291907 intron_variant
G/A 47291935 intron_variant
T/G 47291969 intron_variant
A/G 47292410 synonymous_variant p.Lys160Lys
T/C 47292411 missense_variant p.Tyr161His
A/T 47292415 missense_variant p.Gln162Leu
G/A 47292561 splice_acceptor_variant&intron_variant
A/T 47292562 stop_lost&splice_region_variant p.Ter174Leuext*?
T/C 47292826 intron_variant
G/A 47292833 intron_variant
G/A 47293027 intron_variant
T/C 47293064 intron_variant
A/T 47293069 intron_variant
C/T 47293338 splice_region_variant&intron_variant
C/A 47293339 intron_variant
C/A 47293485 intron_variant
T/A 47294296 splice_region_variant&intron_variant
C/G 47294304 missense_variant&splice_region_variant p.Thr376Ser
G/A 47294388 missense_variant p.Arg404Lys
A/T 47294414 missense_variant p.Asn413Tyr
C/A 47294424 missense_variant p.Ala416Asp
A/T 47294627 missense_variant p.Thr484Ser
A/T 47294629 synonymous_variant p.Thr484Thr
C/T 47294635 synonymous_variant p.Tyr486Tyr
A/T 47294637 missense_variant p.Lys487Ile
C/A 47294799 intron_variant
T/A 47294803 intron_variant
C/A 47294804 intron_variant
A/T 47295174 intron_variant
G/A 47295667 intron_variant
G/A 47295675 intron_variant
G/T 47295686 splice_acceptor_variant&intron_variant
C/A 47295952 intron_variant
C/A 47296034 intron_variant
C/A 47296128 intron_variant
T/C 47296140 intron_variant
A/G 47296150 intron_variant
A/T 47296169 intron_variant
T/G 47296173 splice_region_variant&intron_variant
T/C 47296254 synonymous_variant p.Asp613Asp
C/A 47296263 missense_variant p.Ser616Arg
G/A 47296723 splice_region_variant&intron_variant
A/T 47296803 intron_variant
A/G 47296943 intron_variant
A/C 47296969 intron_variant
C/A 47297029 intron_variant
C/T 47297157 intron_variant
T/A 47297610 intron_variant
T/A 47297619 intron_variant
A/T 47297636 intron_variant
G/T 47297720 intron_variant
T/A 47297846 intron_variant
C/T 47298027 intron_variant
T/A 47298189 intron_variant
G/T 47298670 intron_variant
A/T 47299063 intron_variant
G/A 47299065 intron_variant
T/G 47299069 intron_variant
C/T 47299092 intron_variant
G/A 47299123 intron_variant
T/A 47299188 intron_variant
G/A 47299246 intron_variant
T/A 47299253 intron_variant
G/A 47299284 intron_variant
T/C 47299324 intron_variant
T/C 47299325 intron_variant
C/T 47299330 intron_variant
G/A 47299332 intron_variant
A/G 47299333 intron_variant
C/T 47299334 intron_variant
T/C 47299339 intron_variant
G/A 47299351 intron_variant
T/C 47299365 intron_variant
T/C 47299372 intron_variant
T/C 47299446 intron_variant
T/G 47299450 intron_variant
G/T 47299469 intron_variant
A/G 47299471 intron_variant
A/G 47299482 intron_variant
G/A 47299489 intron_variant
G/T 47299492 intron_variant
G/A 47299501 intron_variant
G/T 47299530 intron_variant
T/A 47299531 intron_variant
G/A 47299535 intron_variant
G/A 47299542 intron_variant
C/T 47299545 intron_variant
A/T 47299553 intron_variant
A/T 47299558 intron_variant
G/C 47299598 intron_variant
C/A 47299604 intron_variant
A/G 47299605 intron_variant
G/A 47299621 intron_variant
A/C 47299626 intron_variant
A/C 47299629 intron_variant
C/T 47299671 intron_variant
T/A 47299683 intron_variant
T/C 47299719 intron_variant
C/T 47299814 intron_variant
A/G 47299816 intron_variant
T/C 47299999 intron_variant
T/C 47300026 intron_variant
C/T 47300068 intron_variant
T/A 47300327 intron_variant
T/A 47300335 intron_variant
A/T 47300338 intron_variant
A/T 47300343 intron_variant
T/A 47300346 intron_variant
T/A 47300354 intron_variant
T/C 47300403 intron_variant
C/T 47300465 intron_variant
G/A 47300488 intron_variant
G/A 47300489 intron_variant
C/T 47300555 intron_variant
T/A 47300580 intron_variant
A/T 47300583 intron_variant
C/T 47300585 intron_variant
T/G 47300702 intron_variant
G/T 47300780 intron_variant
C/G 47300781 intron_variant
A/G 47300811 intron_variant
G/A 47300862 intron_variant
C/T 47301778 intron_variant
T/G 47301971 intron_variant
A/G 47302013 synonymous_variant p.Ala848Ala
C/T 47302509 intron_variant
G/A 47302569 splice_region_variant&intron_variant
T/C 47302766 synonymous_variant p.Tyr923Tyr
T/C 47302793 synonymous_variant p.His932His
A/G 47302970 intron_variant
A/*,T 47303325 intron_variant
T/C 47303336 intron_variant
A/C 47303337 intron_variant
A/T 47303452 intron_variant
C/A 47304060 intron_variant
A/T 47304356 synonymous_variant p.Ala1036Ala

View accession wise SNPs


Sequence Details:

Protein Sequence:
>Vu_33663.1
MVRRLLSRASSEQKIDIELGRTGEERSGSQYKGVKIHGEVLLGFLFICIVQFSHADTDPSDVAAINNLYTALGNPVLPGWVPSGGDPCGQGWQGVRCNGSVIQEIVLNNNHIGGSIPSSLPVTLQHFFLSDNQFTGSIPASLSMLAELTDMSLNNNLLTGEIPDAFQSLTQLINLDLSNNNLSGELPPSMENLSALTSVHLQNNNLSGTLDVLQDLPLRDLNVENNQFVGPIPPKLLSIPNFRNDGNLFNINVNATITPARPPHSPVPVSPSGTVVSGTPSSGRLPTKPTDGPTAAKESNSVKSKKNTKRVVWISISSILMFVIVVLGLLLFVPRCSRREQVNKSSKQHQVGKYGGERQNPREYEGFVQPPSQTEKVPKGAVVRPKGDQEEARRMRAIPKLQGEQEKNEQRMGTIPKLLDHEIDMSSLDVYSMPSPPVPPPPPPLPTESVIVEPTSFHKGANFNPPKKSPVPPTFAKTFTIAALQQYTNSFSQDNLIGLGMLGTVYKAELPDGKDALHSDDEFKTRLSWNARIRIALGAARALEYLHEQCQPPVVHRNFKSANILLDDDVSVRLSDCGLAPLITKGFVSQLSGQLLAAYGYGAPEFESGIYTYQSDVYSFGVVMLELLTGRQSYDKTRARVEQFLVRWAIPQLHDIDALSKMVDPSLKGDYPAKSLSNFADIISRCVQSEPEFRPAMSEVVLYLINMIRKESQQRGSSSIFKVLTFPKFTCKEVLPNQLQRMVACHISVFVMSNYDTNPFAEDEVNPFAEGSANKKASGQSNYVGGVFYNTNSRSASAKLSPLSPEPYDRSATVDIPLDSSEDLKAKEKELQAREAELKRREQELKRKEDAIARAGIVIEENNWPPIFPVIHHDIAKEIPIHLQTIQYVGFTTWLGLMACLLWNIVAVTVAWIKGEGLSLWFLAIIYFIAGVPASYVMWYRPLYRATRTDSALKFSWFFLTYSVHILFCVFAAIAPPIIFKGKSLTGILPAFEVLDGNTVLGILYFIGFGFFTIESLLSIWLIQQVYMYFRGSGKAAEMRREAAKGAMRAAL*


CDS Sequence:
>Vu_33663.1
ATGGTAAGACGATTGCTTTCAAGGGCAAGTAGTGAGCAGAAGATTGACATTGAGCTTGGAAGAACGGGTGAGGAGAGATCTGGCTCACAGTACAAGGGAGTGAAGATCCATGGCGAAGTTCTTTTGGGATTTCTGTTCATCTGCATAGTCCAGTTTTCACATGCAGACACTGATCCCTCTGATGTTGCAGCAATAAATAACTTATATACTGCGTTGGGCAACCCTGTTCTTCCTGGGTGGGTTCCTAGTGGAGGTGACCCATGCGGACAAGGGTGGCAAGGTGTTCGATGTAATGGTTCAGTAATTCAAGAAATAGTTCTAAACAACAATCACATTGGGGGAAGTATTCCATCCAGTTTGCCAGTCACTTTGCAACACTTCTTTCTATCAGATAACCAGTTCACTGGAAGTATTCCAGCCTCTTTATCCATGTTGGCTGAATTGACTGACATGTCTCTTAACAACAATCTTTTAACAGGAGAAATACCAGATGCATTTCAGTCTCTTACTCAATTGATCAATCTAGATTTATCTAATAATAATTTAAGTGGGGAATTGCCTCCATCTATGGAGAACTTGTCAGCTCTGACCAGCGTACATTTACAGAACAATAACCTCTCTGGGACCCTGGATGTTTTACAAGACCTTCCGCTGCGAGATTTGAATGTTGAGAACAATCAGTTTGTTGGACCCATACCCCCGAAGCTGTTAAGCATACCTAACTTCAGAAATGATGGAAACCTGTTTAATATTAATGTCAATGCTACTATAACCCCGGCACGTCCACCTCATTCTCCAGTGCCAGTATCGCCATCAGGAACTGTGGTTTCTGGGACTCCATCATCTGGACGTTTACCTACTAAACCTACTGATGGACCAACTGCAGCAAAGGAATCAAATTCTGTGAAATCGAAAAAGAATACCAAGAGGGTGGTTTGGATATCTATTTCTAGTATATTGATGTTTGTTATTGTAGTCCTGGGACTTCTTCTCTTTGTTCCAAGATGTAGTAGAAGAGAACAGGTTAACAAAAGTTCCAAGCAACATCAAGTGGGAAAATATGGAGGTGAAAGACAGAATCCTAGAGAATATGAGGGATTTGTCCAACCACCTAGTCAAACTGAGAAAGTACCAAAGGGTGCTGTTGTGAGGCCGAAAGGGGATCAAGAGGAGGCAAGGAGAATGAGGGCAATTCCAAAGCTACAAGGCGAGCAAGAGAAGAATGAACAAAGAATGGGAACAATCCCAAAGCTGTTAGATCATGAGATAGATATGAGTTCATTAGATGTATATTCCATGCCTTCTCCACCAGTACCTCCTCCACCTCCACCACTCCCTACTGAGAGTGTGATTGTTGAACCAACCTCATTCCACAAAGGGGCTAACTTCAATCCTCCCAAAAAAAGTCCAGTTCCTCCCACTTTTGCGAAAACTTTCACCATTGCAGCCCTACAACAATATACAAATAGCTTTTCTCAAGACAATCTTATAGGTTTAGGAATGCTGGGGACTGTGTATAAGGCAGAACTTCCTGATGGAAAGGATGCACTCCATTCAGATGATGAATTCAAAACAAGACTGTCATGGAATGCTCGTATCCGGATAGCACTTGGTGCAGCTAGAGCCTTAGAGTACTTGCATGAGCAGTGTCAGCCACCTGTTGTACACAGAAATTTCAAGTCTGCTAACATTCTCCTTGATGATGATGTTTCTGTTCGTCTATCTGATTGTGGTTTGGCTCCATTAATAACTAAAGGTTTTGTAAGTCAGCTCTCAGGACAACTTCTAGCAGCTTATGGCTATGGAGCACCAGAGTTTGAGTCAGGAATTTACACATACCAGAGTGATGTTTACAGCTTTGGAGTGGTTATGTTAGAACTTTTGACAGGCCGTCAGTCCTACGACAAAACACGAGCTCGAGTGGAGCAGTTTCTGGTGAGGTGGGCTATTCCACAACTGCATGACATTGATGCATTATCAAAGATGGTTGATCCTTCTCTAAAAGGAGATTACCCTGCCAAATCATTGTCAAATTTTGCAGACATTATTTCTAGATGTGTTCAGTCGGAGCCAGAATTTAGGCCAGCAATGTCAGAAGTTGTCCTGTACTTGATAAATATGATCAGGAAGGAATCTCAGCAAAGAGGGTCTTCCTCCATATTCAAAGTGCTAACCTTTCCAAAATTCACATGCAAGGAGGTTTTGCCCAATCAGCTTCAGAGAATGGTAGCATGTCATATATCCGTGTTTGTCATGAGTAACTACGACACCAATCCCTTCGCCGAAGATGAGGTTAATCCCTTCGCCGAGGGATCTGCTAATAAAAAAGCATCAGGGCAATCAAATTATGTTGGTGGTGTATTCTATAATACAAATTCAAGAAGTGCTTCTGCAAAGCTTTCACCCCTGTCTCCTGAGCCTTATGATCGTTCAGCAACTGTTGACATTCCTCTCGATTCCTCAGAGGACCTCAAAGCTAAGGAGAAGGAACTCCAAGCCAGAGAGGCTGAGTTGAAAAGAAGAGAACAGGAGCTAAAACGAAAGGAAGATGCTATAGCACGAGCTGGAATAGTTATAGAGGAGAATAATTGGCCACCTATTTTCCCCGTCATTCATCACGACATTGCAAAAGAAATACCAATACATCTTCAAACAATCCAGTATGTTGGATTTACAACTTGGTTGGGTTTGATGGCATGTCTTCTATGGAATATTGTAGCAGTTACTGTAGCTTGGATCAAAGGAGAAGGTCTTTCACTCTGGTTTCTAGCTATCATATACTTTATTGCCGGTGTGCCAGCATCGTATGTCATGTGGTATCGACCTCTTTATCGTGCTACAAGGACGGACAGTGCTCTAAAGTTTAGCTGGTTTTTCTTGACTTATTCGGTGCATATTCTCTTTTGCGTTTTTGCTGCAATTGCTCCTCCAATTATCTTCAAAGGAAAATCTCTCACAGGTATTCTACCTGCATTTGAGGTATTGGACGGCAATACAGTGCTCGGGATATTGTATTTCATTGGGTTTGGATTTTTCACCATTGAATCACTGCTGAGCATTTGGCTTATTCAGCAAGTATACATGTACTTCAGGGGCAGTGGCAAGGCTGCAGAAATGAGGCGAGAGGCTGCAAAAGGAGCCATGAGGGCAGCTCTATGA


Promoter Sequence:
>Vu_33663::LG9:47288991-47290991(+)
ATTAAGGAAAAAAATGATGTGATTTGAGATGAAAGTTTATAAAAATTTGTGTACTATATGATGAGTGTGAGAAATTAAAAAAAAATATTTTATTGAATAAAATTAGATGATTGTCATTTTATCTTTGAAGATAAATATGATATAAATTTAAATGTAATTAGTGAAAATTATATTAAGACAAAACTAAAATTATTATTTTAAAAAAGTTAAGGATGAAATTATTATTATTATTAAAAAAAATAAAATAGATTATTTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATAAAAGAAGGCATCGATTCCTTTATATATATAACTAAGAACCAAATCGATTCTTATATGTATATTTATATAACAAGCGGATAAATTCTTATACGTATGTATACAAGAAGCAAATAAATTCTGTATAAAAAGTGTTCGATTTCGTGAAAAGGTGAATTGATTTTCTGGTTATGATAAAAGAGGAGAATCAATTTGGTTCAAATGTTTGAAATTTTTTTCTTTAAAAGATTTAATTATCTCATTCCCAAACTCCATTTCCAAGCCTTCATCTTCGTCGCTTTTATCCTTTTAGAACCTCCGTCCATGCAAAAAATAATCATATTTCTCCATCATAAACTTAACCAACATCAAATTTACTTAAAATCAAAGGACCTAATGAATAATTTTATTTCTGTGACGTAACTTTCTCTTTCTTAAGTGACATCTAAGAACAAATCAACATTTACAAATCGTTATAAGTTCCCTGATCCAAACAACATCGACTCTCACTCTTCTGTACATATGAACAGTATCCCATATCCAAACGCAACATTAAACTCCCAATGTAAATTGTTACATTTCTAAAAGAAATTTAAGTTTTTCTAATAACAATAATATCTGAAATAATTGTGTAAGTTGAAAATTACCAAGAATATTCAGAAAAAAAATTAAGAAATTTGGTGCTGTGGGCCAATACATCAAACTCACGCGGAGCCATGGCATGTGATTGCACTCTCCATCACCTTGCAAACGTTAACATTAGCATCCCCACATAATAAAATAGAAAAAAAAATTAATGTTAATTAAGATGAATGAAAGAGAGTCATTAAAAAACATTTAAAAATTATTAATTAAGAAATATATAATATATTTTATCTATTTAAAGTGAATATTAAAATTTATTTTTCTGCTTAATTACAAGTGTTTTGTCACATCCAATTTTCTTCTCACTAAGCAGCAAAAACACAATGGATGTAGTATCTGTTGTTCATAACTAATGCTGTTTGACAAATAATTGACTGGTTGTAACAAGGGGACAAGACAAGGCACAACTACATAATAAGCACTCCATTATTAAACATCAAACATGGGCAGCATGTCGTGGTAGAGTAACCCTACGCGTTCACAGAGAGCGTGGCAACGCTAATTTCACCATTCAGATAATAAGACACTACTCGAACAGCACAAACACACTCACTCTCACTCACCCTCGTTCGACCTCTCTGTAGTTTTTAGAGAGAGAGAAATGATTGTTTGTTTTTCAGAATAGAATTCCCTCAGAGCAGCTTTTCCTCTTGTTTCCAGCTTTTTCTAAAGATTGGGATTTTTGCCACAATTTTTCAATCACTTTCATTATAATTAATATACAATGATCATTATTATATTCTATATGCCAAAAGCTTTAGTGCTTACGTTCACCACTCAAACTACTAAATAAGCTATGAATCTTAGCTCTTAAGTTTATTTACTGACTCTACAAAACTAAACTTCATTTTATCTGTTAGTTTATGGTTTTGATCTCGAGATTTTCAGCATTACTTCCCAGGCTTGTTCACTTTCTCTCTTACGTAGGTTCATTTTGTTTCTCAGATTAATCCCTCGTGTTCATGTTTTATATTACTCTACTCAACTTTAACTTTTTTTATTTAAATGACGGCTTTGTTTTAGATTTTTTGGGGGATTAAATTTCCAGAAGAGGA


Gene Sequence:
>Vu_33663(+)
ATGGTAAGACGATTGCTTTCAAGGGCAAGTAGTGAGCAGAAGATTGACATTGAGCTTGGAAGAACGGGTGAGGAGAGATCTGGCTCACAGTACAAGGGAGTGAAGATCCATGGCGAAGTTCTTTTGGGATTTCTGTTCATCTGCATAGTCCAGTTTTCACATGCAGACACTGATCCCTCTGATGGTAACGATTCTATCTTCTTTTTGTCGTCACCTACTTCCCTCTAGATTCATGCTTTGGGTTGATAATTATCCTTCTGTGCCTCTTTTGTTATGTGTCATGCTCAAGGTTTCTCATTTAAATCAAAGTTATGTAACCTTGAGGTTGTGATTCTTTCTCGCTTTCTCGTGACTAATTTTTTTGAAGTATCCTGCCTTTATCTGAACCAATGTGCAATGGGTACTGAATATGTGGCATGGGTGGAATTGTGATGTTTTGTTCTTTTACACTTGCACACATTATTTCTTGATTGTTTATTTCATCTATCTGTGGTGCGTCCTAAGAGTGTTAAAGTTTTGTAATTGGAGCAGTTGCAGCAATAAATAACTTATATACTGCGTTGGGCAACCCTGTTCTTCCTGGGTGGGTTCCTAGTGGAGGTGACCCATGCGGACAAGGGTGGCAAGGTGTTCGATGTAATGGTTCAGTAATTCAAGAAATGTATGTAACCACTTTCTCTTGCTTCTACTTCACATTGATTGAAATGCACAGAATATATAACCAGTAGCTCTTTGTCATTCATGACAGAACTCTGAATGGTGCAAACTTGGGAGGAGAACTGGGTGACAGCTTAGGAAGTTTTGTTTCTATCAGAGCAATGTAAAGACCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGCTCCACTCTTGGTAGTTTTCTTTTTCATCCATCTTTCTGGGTGTCCTCAGGCATGTGCATGGCATGAAAAAGTCCATCTGTTAATGTATGTCTGCATCTTTAGTGCATTTCCTCGGTTCATGTATTGCAGTGGGCGTTCTTCCCCACTGTTTCTCCTGCATTACCTTTACCGATTTTTTCATGTTTATGGGGCAGAGTTCTAAACAACAATCACATTGGGGGAAGTATTCCATCCAGTTTGCCAGTCACTTTGCAACACTTGTATGTGGTAACAAATTTTGTGATATATTTCTTCCAACACATTGTGCAAAATAAATTGATGGTTTGTACTTTTGCAGCTTTCTATCAGATAACCAGTTCACTGGAAGTATTCCAGCCTCTTTATCCATGTTGGCTGAATTGACTGACATGTGAGTTTATTGCATTTTCTCTCTCTTTATCAAATTCTAATGATAGTTGTTAACTGTTAGGCAAATTTATCTAAATGATGTTGAATCATCCCCTTTCAGGTCTCTTAACAACAATCTTTTAACAGGAGAAATACCAGATGCATTTCAGTCTCTTACTCAATTGATCAATCTGTAGGGACTCATTGAATTATTCTTCAAATACTAACATGTAAATTTGAATGGAGATCATTTTAGCTTCGTTAAATATAAAACTTATTTGGTGAACCATAAACTGCTGTGCAGAGATTTATCTAATAATAATTTAAGTGGGGAATTGCCTCCATCTATGGAGAACTTGTCAGCTCTGACCAGCGTGTGAGTATCTTGCCTTAATAAAGATTACCGTTTTAACGTATTTCTCTGTTCTCTGTCAATCAACCTAACTTTTTCTTCATTTGCAGACATTTACAGAACAATAACCTCTCTGGGACCCTGGATGTTTTACAAGACCTTCCGCTGCGAGATTTGTACTTCTCTTAACACGTTTCTTATAAATTTTGCATGATATTAGGTTGGTTAAAATAAAAATCAGTTCTTGCAGTTTCATGCCATAAGATTTTGATCCCTGAGAAACCAGTGCTTTAATAATGGGAAAGTTTAATGATCCTTTCTTCACAAAATAGGGACCTTAGTAAGTAAAAATTACAATGATTAAAATCTAAGTAAATGAAAAATATTGGACAAATAGCTTATTGTTTAATGACATGAGCCAAAATCCAAATTAAATAAATGATAGAAACCAATATTCAGAAGAAAAAAAATTTATGTGAACTGAAAACACATTTGGTGAAAATGTAGTGATTAATTTGTTTTTACCAACTAATTTAAAGAACTGTTGATACAGTTTGTAGAAATTTTGAACCATTTGAATTTGTATAGAATCTTTAACTTTTTAATCGCGTTTATTCTCTTTTAAATTTGTGCCTACTCTTCCCTGTTTGAACAGGAATGTTGAGAACAATCAGTTTGTTGGACCCATACCCCCGAAGCTGTTAAGCATACCTAACTTCAGGTGAAAACCTTAAAGTATTGTTTTCCCATGCTCAATTAAGATGCTTCCTGTGTTTGAAAAATGTGAAGATGGACACGGACTTGTGTGAATTGTAGTTCATTTTCATGAAAATATTTGCGATCATTTTAATTACCAAGACGTGCAGTGTTGTAAGCATTCAGAATAGCAAACAATTGGGTGTCGCGCTGCCTCCACTTATACAGTCAGACAATTGAAACTACACATAATTTAAGATAAAGAAAAAGTCTCAAGTCAAGGTTTTGAGACATATAACTTCAAATGTGCAATTGTGGGTGTGTTTACAACAAAAGTATTAATCAAAGTTTCCTTTATTCTCTGTTCCTTTATTGATTTCTGTTACATCAGTAATTTGAGTGATAATGTCGAAAAAGTATTATACATGAGTAACTTTGGTTCTTCAATAACTGATGATGATTTTGTTATGCAGAAATGATGGAAACCTGTTTAATATTAATGTCAATGCTACTATAACCCCGGCACGTCCACCTCATTCTCCAGTGCCAGTATCGCCATCAGGAACTGTGGTTTCTGGGACTCCATCATCTGGACGTTTACCTACTAAACCTACTGATGGACCAACTGCAGCAAAGGAATCAAATTCTGTGAAATCGAAAAAGAATACCAAGAGGGTGGTTTGGATATCTATTTCTAGTATATTGATGTTTGTTATTGTAGTCCTGGGACTTCTTCTCTTTGTTCCAAGATGTAGTAGAAGAGAACAGGTTAACAAAAGTTCCAAGCAACATCAAGTGGGAAAATATGGAGGTGAAAGACAGAATCCTAGAGAATATGAGGGATTTGTCCAACCACCTAGTCAAACTGAGAAAGGCAAATATATATAACTTTTGGTCTCTCTAATTTTGTTTCTGTTATTTAATTTTTTGTTGTGAGGATTTCACTAATATAATCATTGCACTTTCTAATGATCTTTTATTTACTTAACTTAATAGTACCAAAGGGTGCTGTTGTGAGGCCGAAAGGGGATCAAGAGGAGGCAAGGAGAATGAGGGCAATTCCAAAGCTACAAGGCGAGCAAGAGAAGAATGAACAAAGAATGGGAACAATCCCAAAGCTGTTAGATCATGAGATAGATATGAGTTCATTAGATGTATATTCCATGCCTTCTCCACCAGTACCTCCTCCACCTCCACCACTCCCTACTGAGAGTGTGATTGTTGAACCAACCTCATTCCACAAAGGGGCTAACTTCAATCCTCCCAAAAAAAGTCCAGTTCCTCCCACTTTTGCGAAAACTTTCACCATTGCAGCCCTACAACAATATACAAATAGCTTTTCTCAAGACAATCTTATAGGTTTAGGAATGCTGGGGACTGTGTATAAGGCAGAACTTCCTGATGGAAAGGTATGACTTTTGCATCTTAATAGCATTGATGTTTATGGAATCTACTGATGAAAAGTCGTAGACACTAGCTTTTTGTGTGTTGTTCCTGTCTTCTTCATCTTTATTGTTGTGGCTTATGATTTATCTTTCTAAACTTTAATCATTGTAAGGTAGCTACTGTTGTCTTATCTGGATAGGTGATATTTGTTTTGGCACATGTTTGAGTACTGTTATGTTTGAATGCTTTTTTATTCAAGTTCCACCATTTGTGTTTCATTTGCCCCAACACTTGTAAATTTAATATATATATATATATATATATATATATATATATATATATATATATATATATATATGGTGATTGGTACTCAAATTTTGACACTCACTCTCATTATATGAATTGCTAGATACTTGCTGTGAAGAAACTAGACAAGAGAGTTTCTAATGACCAAACAGATGATGAGTTTCTTGATTTGATAAACAACATTGACAGAATCCGGCATGCAAATATTGTTGAGCTTATTGGATACTGTACCGAACATGGTCAAAGGCTTCTTATTTATGAGTACTGTAGTAATGGTTCATTGCAGGATGCACTCCATTCAGATGATGAATTCAAAACAAGACTGTCATGGAATGCTCGTATCCGGATAGCACTTGGTGCAGCTAGAGCCTTAGAGTAAGTCAATCAATAATCAAGTTTAGACATTAGGGAAAAATATTTGTCCCTAGCTGTCAATTTTCTGTAAATAGTCACTTGAATGTTTCCGTTTCTATATTTAATTTCTCTTGCCTGGATTGTCATGTATTTCTCAGTGGGTTAATTAATTTAATGCTGGAGTTTTTTACTAGAAACTTGGGATCAGTTCACTATTACATGGTAGAACCTTTTGAGGTTTAAGTTGCTAAAACATTATAGTAGATGTCCATTGACGATAATGTCTTTTGATGTGCTACTTCTGAATCTAACACTGTAATGTTGTTCCCGACAAGGTACTTGCATGAGCAGTGTCAGCCACCTGTTGTACACAGAAATTTCAAGTCTGCTAACATTCTCCTTGATGATGATGTTTCTGTTCGTCTATCTGATTGTGGTTTGGCTCCATTAATAACTAAAGGTTTTGTAAGTCAGGTAAGAAATCATTGCATAATGTAAAAAATATGCCTCTGCATCATTGCTGATTATTGTAATTTCATGTTTTGTTTAAGGTCCCTCCCCTCCATCATGACTAGGCAATAACTGAGAATTTGAATAATTCGCATAGGCATATGAATATTGATAACTTATAGCCATAAGATTGGCAGTTATTTTCACTCAAAAAGAAAACTTCAAAATCATCCTAAATGAACATGCTTCCTGTGAAATGTAAACTTCGATTTGCCTATTTCCTGTGAAGTATCGTGCAAGCATTATGTCAATGGTTCTTAGCATAGCGTAAAAAACATTGTTATTTGCATTATATAACATTCCAAGCATTTTCAGCTCTCAGGACAACTTCTAGCAGCTTATGGCTATGGAGCACCAGAGTTTGAGTCAGGAATTTACACATACCAGAGTGATGTTTACAGCTTTGGAGTGGTTATGTTAGAACTTTTGACAGGCCGTCAGTCCTACGACAAGTGAGAGCCAATAACTGAAGTATTTCTGCTTCTATTTTCATCTATTTATGAGTTACTTCATCTATTCTGAAAATCTTGGACAGAACACGAGCTCGAGTGGAGCAGTTTCTGGTGAGGTGGGCTATTCCACAACTGCATGACATTGATGCATTATCAAAGATGGTTGATCCTTCTCTAAAAGGAGATTACCCTGCCAAATCATTGTCAAATTTTGCAGACATTATTTCTAGATGTGTTCAGGTAAGCTTCTTTTTCTCTGAATTTAGAAGTGTCGCTTAGCTTACGAATCTCTTTGTCATGAAATTGGATTTGGCCTTATGTTATGCAGTCGGAGCCAGAATTTAGGCCAGCAATGTCAGAAGTTGTCCTGTACTTGATAAATATGATCAGGAAGGAATCTCAGCAAAGTGAATCAAATGAATAAATAATTATGGAAAGTAGTGATATTTGAAGATGATTACATCTACAAAGAATTTCATGCATGATTGCATGTCACCAAGGAGGGTCTTCCTCCATATTCAAAGTGCTAACCTTTCCAAAATTCACATGCAAGGAGGTTTTGCCCAATCAGCTTCAGAGAATGGTAGCATGTCATGTCAGTCCTCCCACTCATGGGTAGCTCTTAATTTATTATTATTAGTTAATAGTTCTCTTAACATACTATGTTGGAGGTTACTAGAAATTAAATTAAACTCATTTGTTTCAAGATAGATTCCGTAGTGTTGATATAGAAATATTATTCATTGTACACATTCAAACTTTGCAATCTTATATGATGGTTGTCCATCAATATTAATAGGATAAAGTAATACTTACAATAATTCACCAATCATAAAATAAGTACATTGTAGGACACCTATTATGTTTTCTTTAATTCATATTATTATATAGTTGTAAACAACTCTTACTTTCATCCATGTCTAATTACTAACTCTCAATAATTACAAAACCTTTAACTTTCCGTCCTTAAAACTAAAAGCTCTTTATTTTAATTTCTATAAATATTATTCTAATCCTTTTTTATCTTTAAAATTTTTTAGTCCTTATTATTCAAGTTTAGAGGGACTAAATGAAAATTTAAAATGATATATATATATATATATATATATATATATATATATATATATATATATAAGAAATACAAAAGGTAGTTTAAAAAAATTGTAGAACTAATAATTTGGACTGGAGTATTTATTTTATTTATAGGTTGTAGAACTGAAATTCAAGGTATTTTAATTTTAATGAATGTTTTTCTTATCTATGTAATAATTATCTTTCATCTCAAGAACTAATACCTTGTAAAGGTGTAACGTCTCATTTCAAAGGGTCCAAAAATATTAATCATATCTGATATGGCTAAACTCAAACAAGAAAGGGGCAAAAACGGAAAACAAAAATCGCATGAAGGGACGCTGGTATAGCAAGACAAAATTATGCATGCAAATTTTTCCCTCTCCATCGGTGATTTTTTGTATGACATTATTGTGTTGGTAACGCGCCCACTAGTTTCTCTCCGTCCCTCTTCACTTTTCTTTCAACTTTGGCGTCAACAAACAAACATGGTAAAGCAAAGAAAAACCGTTCATTTCTATTCCCTTGGCTACCAACAAATATCTTAATTCCCTCATTTTTCGACGCTATTCTCATTTCTCTTCTCACCGAATCTTTTATCCATTTTCTTCTATCTCTTCTCTCTTCAGTTTTATTACATCTCTCTCTGTCTAGATATCCGTGTTTGTCATGAGTAACTACGACACCAATCCCTTCGCCGAAGATGAGGTTAATCCCTTCGCCGTAAGTTTCTTCCCTAACTATTCTCTTTTTATCCATTCTTCTCTCATTCAATTAATTAATTGACATAAATTGACTTGCTGTTTCATCTTCTCTGCATGCTTCTCCATAACATTAGGACTTTCAATTATCTGATACGTGTGTCATTGCTAAATTGAATGGCATTCATAATGTAGCTATACGGAGTGATTTTGATGCGATTGTTTCGAACACTGTTCAATGTTAATTTAGACTCTGTTCGTGTAGCGATCAAATCTTAGAACGGAAACTTGAAAACAAAACGTTGCTCATGAATGACGCCACATGTAATAATTCTGTGGCACATTAATTCTCTCTGTTTCTACGGAGCAGGTTTTAGATTGTGGATGTATGTATGTGATGCCATGGCAACCTCTCCGTTGCGGTGGCCGCCACATTCGCGCCATTTTCTAATTGCCAACCTAACATTATGATATCCGACTGCTGATAAAAGAAAACTAGAATATTATATTAGTTTTTAGTTGTCTGTGTAATTAGTTATTTTTTAAAGTAAAATACATATTTGCGGAAAAAAATTATCAATTGCGTGAATCATAAATGTAAAATATTTTTAATATATACACACACATACGTATAAAGTTAAGTATTGAATTTAATTTATACGTATGGTTTCTTAAACACATTTGATAGAATATTATTTAAACTGAACTCAATTGGCCCATATTATTTTGAAAGAAAATTTAAAGAATACACATAAAAGATAGAGAAAATATCTGTATATTTTAAAAATTATTTTTATTTTTGGTAAAAAAAATATATTACAATCTGTTAGGAAACAATTTATGAATATTTCAAAAGTTATATATCTTCTTTTGGTATTTCTTACATGGTTTGATCCTGATCCAAGAATATTAGGACCAGAAAAAATCTAAATGGCTAAAAAGCTCTCATAGAAAAAACTCACAAGACTACAAAAGTCATGTGGTTCAGGACCAACCCATTATTTTGCTTTTAGAAAAAATATTCATTTTGAATATAAGAAGAAAAAAATGTAATTAGCTTCTAATTTTTTGCAAATCTAAGTGCTTTTAATTTGTCAAATAATTATATTCAAACATTTTAATTAGATAAAATAGATTTTGTAAAATATTTTAATAAACTTGATTGCTTGCTTATATAGGAAAATTATGCAACAACATAGAATAATGAAATTTTTGACTGACTAAATATATTTAATTTTTTTTGACTGACTAAATATATTTTTAAAGTATATAAGATAGTTATTTAATTTTGATGTGCAAAAACTTCATGTATATTTTTCATATAAACATATTTAAGTAAGTAATTTCTTTTTTTTTTCAATGAATTTTTATCAAAATTAACAAGAAATTATTTACAATATTAAGTGGTTTATGATGTATCATTTCTTAATATTCACTAAATTTTGTATTGCTATTAGAACGAATACTAAAATATTATATGCATTTTCTATGCTAGTTGTTATTAATTCAATTGTTCAACATGCATGTAGTTTATTGGTTTATCATTTTTCTATCTTGTAATTTTTTTAATCATACATATATATTTCAATTATTCTTTTTGTTGATTGATTCACTTATATGATTTATCATCATATGTAAAAAAAGTGATATGAAATGTTATCTTTAAATCAAAATTTTAAAATATAATTTTATTGATTTTTTTTTATATTATGTTTTAACATGAAACTTCTATCTTTATGTTTAAATTTCTAATCACTTTGATTTTCTTCTTTCTAGAATTAAAAGAAATTAAAAATTATTAAAATGTTATAAAAAAACATACATAATATATAAAAATCAATTATTTATCACAATATAACAAAATTAACTTCTTAGCAAGTCATTTATATCATTTATATCTTTTAAAATGTTTATTTGATTTTAAATAAATTAAAATCTAATTAATACAAAGAAAAGTCATTTTATTTATTTAACATGAATTTCTTTTTACAAAGACTACATTTGGTTAGGAAATGTTAGAAATAATAACGCGAGTTTTTTTTTAACAAAAATTAACAATTAATAAAATTATTAAATATTTGATGTGGTCGTGATATATGAAAAAAATATGAAATGTTATTTTATACATGAAAATTGTTATATATATGAGTATGATATAGAAATATAAAAATACGTATTTTATTTAATAACATAAGTATGTTATAAAAATATTTATTTAAATATAATAAAATTACAACATATTAAATTATTTAATATAATATATAATTTTATATGTATATATATAAATGATATTATTTCTAAAAGTTAATTAAAATTTTGTAGTGAAATTAAACTACCTTAATCCTGACTCATTTGAGAAAATACTATGGGGGTTGGGGACTTTTATTTTGTCCCACACTTGAGGGTAGACTTCTTAAAATGGAGTTTTTTCAAGAGTGAGTTGGATTAGCCCATAGATTAAGTTGACAACATGAATCAAGTTGACAACTCTACTTAAAGCTTTGTTTCAAATTAGTGCCACTAAATTATTTTGAACACTTAGTAGAAAAAATGAAAAATACTCATATAATGGAAATCCAAGTTTTAATAAAGTTTCAAAAGAATGTTACTAGAATTTAAGAAAAAGTTTTCATTTACTGATTTTTTCAATCATAATGTTTTTTGAATTATTTCCGTATTGCTTTGTTATGTTATGCTTATTCGTATTCAGAAAATAAAATAAAAAACCAAAGAAAATGAAATAATGAATTGACGTTAGCAGATATGCCAATATATTGATATATTCGTAAAATGTGTAAAGCTATTCTCTATTCGTACTTTTTTATGAATACTCTCTCTTTTCGTATTTAAGAAAGAAAAAATATGTTGTCTTTTTTTTATGAAATTCTTTGTTTTCAATTGTTGCATTAATTGATTTGTTCTTAAATTAATTAATTTTCACGATTTTACTAAAAGAGATTTATAAATGTCTGAACTAAATAATATAAAGTTTTTCTGTCTTAATTTAATGGGAAAATATGAATATTTGACATAAAAGTTTCACTCAACAATTTCAATTTTAAATTAGACAGAGGTTTTTTTTCATCATACAAAAAAATATAACAATGATAACTATAGATTAGCAATACAGTTTTTTAACTAATTTATTGATTTATTAAAGGTGTGAAGTGAATTAGTTGAAAGCTTTTTATAAATAATAACAGATAGGATATTAATCATAGTACGGGTTAATTAAGAAATAAATAACGATAAAAACAAATACAATGACCAATCATAAGATGTAGAAGAAATAAAGAAACTAATCATAATTAAGATACTTTAGATATGATAAGGTAATTTTTTATATTCTATAATAATAATTTTACCATCTAAAAATTTATGTACTTCCAATAATGTATTAGGAGGGATCTGCTAATAAAAAAGCATCAGGGCAATCAAATTATGTTGGTGGTGTATTCTATAATACAGTAAGTTCTTCCTTCCATGTCATTACTACCATTATATTAACTTATAATCAAATCGTGACCTTTGTTTTTATTTTTCAAAAAAAATCAGAATTCAAGAAGTGCTTCTGCAAAGCTTTCACCCCTGTCTCCTGAGCCTTATGATCGTTCAGCAACTGTTGACATTCCTCTCGATTCCTCAGAGGTACACCATATTATGAAAATGTTGAAAGAAATGTAAAAACTGTGCTATATGAATTTTGCTGACCAAATTTTTAATTGTGTAAATTGTTATCTTATAAGGACCTCAAAGCTAAGGAGAAGGAACTCCAAGCCAGAGAGGCTGAGTTGAAAAGAAGAGAACAGGTGATATATCAATGACTTACGCAATGAGTTAACTTGCCACTTACAAGATGTTGAGTTAGCTGATTAACTCGTGATATTATGTTTTGTAGGAGCTAAAACGAAAGGAAGATGCTATAGCACGAGGTATTTTGAGTTCATTTATATATTCCAGAACCCAACAGAAGTTAGGTGGCTTACACTTTGATTTTGGTTTTTTTGCAGCTGGAATAGTTATAGAGGAGAATAATTGGCCACCTATTTTCCCCGTCATTCATCACGACATTGCAAAAGAAATACCAATACATCTTCAAACAATCCAGTATGTTGGATTTACAACTTGGTTGGGTATGTTAAAGTCTATACAACTTTTTTTTGTCAAAGGTTATGTTTTAGTCATAGCTTCTTGTTTCCTCATAATTAGTTAACACAATCGTATCTGGGACCATTGTTTCAAAGTCATATAATAATTAGTATCAGGACCATTGGAGACAAATTCTGAATTAAATAATTAAATAGATATTGAAATTATTTAAAGCTTATTTATATCTTTAATTATATGGAGTAACTGGTGAACATTTAGTCTATTAGCACTCTCAAATATGACATTCCTGTTTATGAAAAAGTTTCTGGTATAACATCCTTCCATCAACACATATACCTTTAATGTCCATACCATCATTTTGAACATTTTAACTGTCTACAGGTTTGATGGCATGTCTTCTATGGAATATTGTAGCAGTTACTGTAGCTTGGATCAAAGGAGAAGGTTTGCTTTGCAATTAGATATTGGACCATTAAACATAGTAGGAAATAATGTTGTTTACACGAACTTCGTTTTGTCTTGCTTGACTTGTAGGTCTTTCACTCTGGTTTCTAGCTATCATATACTTTATTGCCGGTGTGCCAGCATCGTATGTCATGTGGTATCGACCTCTTTATCGTGCTACAAGGTAGTTTTCTATTTTCAATTCTTCTAGCTTTGCATGGTGTTCAAGATGTATTTAGCCTTTTCCTAAACTAAAAAAGTAATTGTTAATGTGGTTCACATGAGCTTTTTGGCCACAGTGAAGTATCAGACTTTTTCTGTAGCAGCAGCATATACATACATTTAGGGAATTTGTAGGCAGACTTTAAATCCAATAAAAGACAACTCTGTCATTGTGAAACTAATATGTTTGGGCATGCAATGTTTACATTATGAAAATGAATACCTTAGCCTAGTTTTGTCCAGTGGAAGGGAGGCCAAAAAGATAGAGTAGGATTGTTACTTTGGAGGCCATTCCTTTCGATGTTATCTCTAAATAACTTGAAATTTCTCATAATGGTTAAACATTAATGGATTTCAAATTTTGGGATTAAGGTTCATGAATTTGTTTAATGTGTGAAACAGAGCACATTAAAGTAAAAGCTAAAATAAAATAATACTTATTATGGTTATAATACATTATTATAATAATAATAATAATAATAAGTATCATCACTACTAAAATAAACAAAAATGTATTTATAGTATATAAAGTATAGAACTAAAAATATTGAATCTTACTAGTCTGTATATCATAGCCATTTAGTATAAGAAGTTCTTGATTCTTTGTTTGTCCCCTCTCTCATTATTAACACTCAAAATTAGAATGTTGTGTTTAATAATTTTGGGTCATCTTCTGTTTCAGGACGGACAGTGCTCTAAAGTTTAGCTGGTTTTTCTTGACTTATTCGGTAAGTTTTACATACTTCCTACTTGTTCTCATTCTTTTGCTCCAGTTTCTTGAAGTGTTCTTATCAATTTTTCCCGTTCCTTCCAAACAGGTGCATATTCTCTTTTGCGTTTTTGCTGCAATTGCTCCTCCAATTATCTTCAAAGGAAAATCTCTCACGTCAGTTCCTTTCTTAAACTACAATCTTTTAATTTAGGACAAGGGTATTTGACATTAGAAATTTTTTACACCCAATTGATAGTATCCTACATTATTTTTTTAATTTCTTTTTTAAATTTAAAAATTAGTTTTTGTTAAGATACCACTTTGATCAGTTATATGTTATTGCTATATGCTCCTTGTGCATCGTGGTTGCTTTTTTACTTGAATTAACAGTTGTTATATGATGTTACGTTGTGGGCAGAGGTATTCTACCTGCATTTGAGGTATTGGACGGCAATACAGTGCTCGGGGTATGTACCACTGTTGTTACTTTGTTGCTTACATTTTATTATTCTTTAACAAGGGAGGGGCAATTATATTCCATGATTAAATGACGCTAAAAGCGCTCAATTACAGATATTGTATTTCATTGGGTTTGGATTTTTCACCATTGAATCACTGCTGAGCATTTGGCTTATTCAGGTTTTCCATAATCCTAGATTTACTTTGTTGCATTCTTATGACTTTACTGCTTTCTTTCTTTATATTTAATTTATATCTTTGCAGCAAGTATACATGTACTTCAGGGGCAGTGGCAAGGCTGCAGAAATGAGGCGAGAGGCTGCAAAAGGAGCCATGAGGGCAGCTCTATGA